108530-01-4

Upstream product

• 492-41-1 (1R,2S)-norephedrine 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 211869-52-2 (4S,5R)-2-Allyl-3-methanesulfonyl-4-methyl-5-phenyl-[1,3,2]oxazaborolidine 
• 139192-62-4 (S)-2-((2S,4S,5R)-3-Methanesulfonyl-4-methyl-5-phenyl-oxazolidin-2-yl)-cyclohexanone 
• 139192-53-3 (R)-2-((2S,4S,5R)-3-Methanesulfonyl-4-methyl-5-phenyl-oxazolidin-2-yl)-cyclohexanone 

Relevant academic research and scientific papers

ENANTIOSELECTIVE ADDITION OF CHIRALLY MODIFIED METHYLTITANIUM REAGENTS TO AROMATIC ALDEHYDES

N-Sulfonylated derivatives of norephedrine are excellent ligands for chirally modified methyltitanium reagents, the latter reacting enantioselectively with aromatic aldehydes (ee ca. 90percent) to form R-cunfigurated carbinols.

Enantioselective synthesis of optically active homoallylamines by nucleophilic addition of chirally modified allylboranes to N-silylimines

Enantioselectivity in the allylboration of W-silylimines with a variety of chirally modified allylboron reagents has been examined. Optically active N-sulfonylarhino alcohols (16,17 and 19) derived from D-camphor and norephedrine were found to be efficient chiral ligands for the allylboration reagent. These reagents smoothly reacted with Ar-silylimines to give the corresponding homoallylic amines in a high level of enantioselectivity up to 96% ee.

Diastereoselective synthesis of enantiomerically pure 3-organosulfonyl-2-(2-oxocycloalkyl)-1,3-oxazolidines from 2-formylcycloalkanones and β-aminoalkanols

The title compounds (3-arylsulfonyl- or 3-mesyl-2-(2-oxocycloalkyl)-1,3-oxazolidines) belonging to two different diastereomeric series, are prepared selectively by variation of the condensation conditions. By this, the chiral information of the 2-amino-1-