108535-33-7Relevant articles and documents
Efficient synthesis of optically pure 1,1,1-trifluoro-2-alkanols through lipase-catalyzed acylation in organic media
Hamada, Hiroki,Shiromoto, Mizuho,Funahashi, Makoto,Itoh, Toshiyuki,Nakamura, Kaoru
, p. 2332 - 2336 (2007/10/03)
Lipase-catalyzed esterification was successfully utilized for the optical resolution of 1,1,1-trifluoro-2-alkanol 1 when racemic 1 was treated with lipase from Candida antarctica in hexane in the presence of molecular sieves (4 A) to provide the corresponding (S)-acetate 2 in an optically pure state. Alkanol 1 is known as an important component of liquid crystal compounds which display remarkable ferroelectric liquid crystal (FLC) characteristics. Five types of optically pure alkanols, i.e., 1,1,1-trifluoro-2-octanol (1a), 1,1,1-trifluoro-2-nonanol (1b), 1,1,1-trifluoro-2-decanol (1c), 1,1,1-trifluoro-2-undecanol (1d), and 1,1,1-trifluoro-8-(benzyloxy)-2-octanol (1e), were thus obtained by the lipase-catalyzed acylation.
Stereoselective Synthesis of Fluorinated Materials Catalyzed by an Antibody
Kitazume, Tomoya,Lin, Jenq Tain,Takeda, Mitsunori,Yamazaki, Takashi
, p. 2123 - 2126 (2007/10/02)
A monoclonal antibody, elicited by a transition-state analogue for the hydrolysis of fluorinated esters, acted as an enzymelike catalyst for the preparation of chiral fluorinated compounds. The syntheses of (R)- or (S)-1-(fluoroalkyl)alkanols and an allyl
SYNTHETIC APPROACH TO STEREOISOMERS OF ALLYLIC ALCOHOLS POSSESING A TRIFLUOROMETHYL GROUP
Kitazume, Tomoya,Lin, Jeng Tain,Yamazaki, Takashi,Takeda, Mitsunori
, p. 177 - 188 (2007/10/02)
A number of stereoisomers of optically pure allylic alcohols with a trifluoromethyl group were prepared, utilizing the enantiotopic specifity of assymetric hydrolysis of their acetates by hydrolyses.Their absolute configurat