108554-34-3

Basic information

• Product Name: 4-OXO-PIPERIDINE-3-CARBOXYLIC ACID METHYL ESTER
• Synonyms: 3-CARBOMETHOXY-4-PIPERIDONE;4-OXO-PIPERIDINE-3-CARBOXYLIC ACID METHYL ESTER;4-Oxo-3-piperidinecarboxylic acid methyl ester;3-Piperidinecarboxylic acid, 4-oxo-, Methyl ester;3-(Methoxycarbonyl)piperidin-4-one;Methyl 4-oxo-3-piperidinecarboxylate;1H-Indole-2-carboxylic acid, 2,3-dihydro-6-methoxy-
• CAS NO: 108554-34-3
• Molecular Formula: C₇H₁₁NO₃
• Molecular Weight: 157.17
• Product Categories: pharmacetical
• Mol File: 108554-34-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 249℃
• Flash Point: 105℃
• Appearance: /
• Density: 1.150
• Vapor Pressure: 0.023mmHg at 25°C
• Refractive Index: 1.461
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.00±0.20(Predicted)
• CAS DataBase Reference: 4-OXO-PIPERIDINE-3-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-OXO-PIPERIDINE-3-CARBOXYLIC ACID METHYL ESTER(108554-34-3)
• EPA Substance Registry System: 4-OXO-PIPERIDINE-3-CARBOXYLIC ACID METHYL ESTER(108554-34-3)

Safety Data

• Hazardous Substances Data: 108554-34-3(Hazardous Substances Data)

Usage

Uses

Methyl 4-?Oxopiperidine-?3-?Carboxylate is a reactant used in the synthesis of potent inhibitors of nicotinamide phosphoribosyltransferase. Also a reactant in the preparation of potent cytotoxic agents which are phenanthrene-based tylophorine analogues.

InChI:InChI=1/C7H11NO3/c1-11-7(10)5-4-8-3-2-6(5)9/h5,8H,2-4H2,1H3

Upstream product

• 57611-47-9 1-benzyl-4-oxo-piperidine-3-carboxylic acid methyl ester 

Downstream Products

• 17038-83-4 methyl 1-acetyl-4-oxopiperidine-3-carboxylate 
• 193274-04-3 3a-(R)-Benzyl-2-methyl-2,3a,4,5,6,7-hexahydro-pyrazolo[4,3-c]pyridin-3-one 
• 193274-00-9 3-(R,S)-Benzyl-4-oxo-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester 
• 193274-02-1 2,3a,4,5,6,7-hexahydro-2-methyl-3-oxo-3a-(phenylmethyl)-5H-pyrazolo[4,3-c]pyridine-5-carboxylic acid 1,1-dimethylethyl ester 
• 193275-28-4 3-benzyl-4-oxo-piperidine-3-carboxylic acid methyl ester 
• 620159-23-1 3a-benzyl-3-oxo-2,3,3a,4,6,7-hexahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester 
• 193274-12-3 3a-benzyl-2-ethyl-3-oxo-2,3,3a,4,6,7-hexahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester 
• 193273-66-4 2-amino-N-[2-(3a-(S)-benzyl-2-methyl-3-oxo-2,3,3a,4,6,7-hexahydro-pyrazolo-[4,3-c ]pyridin-5-yl)-1-(R)-benzyloxymethyl-2-oxo-ethyl]-isobutyramide 
• 193273-66-4 capromorelin 
• 193274-59-8 3-(R)-benzyl-1-[3-benzyloxy-2-(R)-(2-tert-butoxycarbonylamino-2-methyl-propionylamino)-propionyl]-4-oxo-piperidine-3-carboxylic acid methyl ester 
• 193274-09-8 {1-[2-(3a-(S)-benzyl-2-methyl-3-oxo-2,3,3a,4,6,7-hexahydro-pyrazolo[4,3-c]pyridin-5-yl)-1-(R)-benzyloxymethyl-2-oxo-ethylcarbamoyl]-1-methyl-ethyl}carbamic acid tert-butyl ester 
• 193274-08-7 {1-[2-(3a-(R)-benzyl-2-methyl-3-oxo-2,3,3a,4,6,7-hexahydro-pyrazolo[4,3-c]pyridin-5-yl)-1-(R)-benzyloxymethyl-2-oxo-ethylcarbamoyl]-1-methyl-ethyl}carbamic acid tert-butyl ester 
• 193274-65-6 {1-[2-(3a-(R)-benzyl-3-oxo-2,3,3a,4,6,7-hexahydro-pyrazolo[4,3-c]pyridin-5-yl)-1-(R)-benzyloxymethyl-2-oxo-ethylcarbamoyl]-1-methyl-ethyl}-carbamic acid tert-butyl ester 
• 193274-15-6 {1-[2-(3a-(R)-benzyl-2-ethyl-3-oxo-2,3,3a,4,6,7-hexahydro-pyrazolo[4,3-c]pyridin-5-yl)-1-(R)-benzyloxymethyl-2-oxo-ethylcarbamoyl]-1-methyl-ethyl}carbamic acid tert-butyl ester 

Relevant articles and documents

Preparation method of nicotinic acid derivative

The invention relates to a preparation method of a nicotinic acid derivative. The method comprises the following steps: with N-benzylpiperidine-4-keto-3-formate as a raw material, carrying out a hydrogenolysis reaction to obtain piperidine-4-keto-3-formate; performing halogenation reaction with a certain amount of a halogenation reagent to obtain 3,5-dihalogenated piperidine-4-one-3-formate or 3,5,5-trihalogenated piperidine-4-one-3-formateperforming one-pot process with different alkaline reagent for removing halogen hydride through elimination, and performing hydrolysis and performing acidification with hydrochloric to generate corresponding nicotinic acid derivatives: 4-hydroxynicotinic acid, 4-aminonicotinic acid, 4-hydroxy-5-chloronicotinic acid, 4-amino-5-chloronicotinic acid and 4-amino-5-bromonicotinic acid. The method is simple and convenient to operate, mild in condition, short in technological process, low in wastewater amount, environmentally friendly and low in cost, and green industrial production of the nicotinic acid derivative is facilitated.