52834-09-0

Basic information

• Product Name: 4-Amino-5-chloronicotinic acid
• Synonyms: 4-AMINO-5-CHLORO NICOTINIC ACID;4-amino-5-chloro-3-Pyridinecarboxylic acid
• CAS NO: 52834-09-0
• Molecular Formula: C6H5ClN2O2
• Molecular Weight: 172.57
• Product Categories: Pyridine
• Mol File: 52834-09-0.mol

Chemical Properties

• Boiling Point: 371.5 °C at 760 mmHg
• Flash Point: 178.5 °C
• Appearance: /
• Density: 1.577 g/cm³
• Vapor Pressure: 3.54E-06mmHg at 25°C
• Refractive Index: 1.66
• Storage Temp.: 2-8°C
• PKA: 2.57±0.10(Predicted)
• CAS DataBase Reference: 4-Amino-5-chloronicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-5-chloronicotinic acid(52834-09-0)
• EPA Substance Registry System: 4-Amino-5-chloronicotinic acid(52834-09-0)

Safety Data

• Hazardous Substances Data: 52834-09-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
4-Amino-5-chloronicotinic acid is utilized as a key intermediate in the synthesis of various pharmaceuticals for its ability to be incorporated into the molecular structures of potential drugs. Its presence in drug molecules can modulate their pharmacological properties, such as potency, selectivity, and bioavailability.
Used in Organic Synthesis:
In the realm of organic synthesis, 4-Amino-5-chloronicotinic acid is employed as a versatile starting material for the creation of novel organic compounds. Its reactivity and functional groups make it suitable for a variety of chemical reactions, facilitating the synthesis of complex organic molecules.
Used in Agrochemical Development:
4-Amino-5-chloronicotinic acid also finds application in the field of agrochemicals, where it is used as a precursor in the synthesis of bioactive compounds for agricultural use. Its potential to be tailored into molecules with specific pesticidal or herbicidal properties makes it a valuable component in the development of new agrochemical products.
Used in Materials Science:
In materials science, 4-Amino-5-chloronicotinic acid is applied as a precursor for the synthesis of functionalized materials. Its chemical structure allows for the engineering of materials with tailored properties, such as improved conductivity, catalytic activity, or specific binding affinities, which can be leveraged in various high-tech applications.

InChI:InChI=1/C6H5ClN2O2/c7-4-2-9-1-3(5(4)8)6(10)11/h1-2H,(H2,8,9)(H,10,11)

Upstream product

• 7418-65-7 4-aminonicotinic acid 
• 1073182-72-5 4-tert-butoxycarbonylamino-5-chloro-nicotinic acid 
• 108554-34-3 methyl 4-oxonipecotate 
• 57611-47-9 1-benzyl-4-oxo-piperidine-3-carboxylic acid methyl ester 

Relevant articles and documents

Preparation method of nicotinic acid derivative

The invention relates to a preparation method of a nicotinic acid derivative. The method comprises the following steps: with N-benzylpiperidine-4-keto-3-formate as a raw material, carrying out a hydrogenolysis reaction to obtain piperidine-4-keto-3-formate; performing halogenation reaction with a certain amount of a halogenation reagent to obtain 3,5-dihalogenated piperidine-4-one-3-formate or 3,5,5-trihalogenated piperidine-4-one-3-formateperforming one-pot process with different alkaline reagent for removing halogen hydride through elimination, and performing hydrolysis and performing acidification with hydrochloric to generate corresponding nicotinic acid derivatives: 4-hydroxynicotinic acid, 4-aminonicotinic acid, 4-hydroxy-5-chloronicotinic acid, 4-amino-5-chloronicotinic acid and 4-amino-5-bromonicotinic acid. The method is simple and convenient to operate, mild in condition, short in technological process, low in wastewater amount, environmentally friendly and low in cost, and green industrial production of the nicotinic acid derivative is facilitated.

HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME

A hydrazide compound represented by the formula (I), an N-oxide thereof or suitable salt thereof: has excellent pesticidal activity.

Inhibiting the growth of weeds with 2-substituted pyrdidopyimidines and salts thereof

2-Substituted pyridopyrimidines and their alkali and alkylamine salts as herbicides, and processes for the synthesis of starting materials leading to the preparation thereof.