108620-29-7Relevant academic research and scientific papers
Synthesis of novel thiazolidine-4-one derivatives and their anticancer activity
Mahmoodi, Nosrat O,Mohammadi Zeydi, Masoud,Biazar, Esmaeil,Kazeminejad, Zahra
, p. 344 - 350 (2017)
This paper describes the synthesis of a novel series of 1,3-thiazolidine-4-ones 6a-n by cycloaddition reaction of N-aryl-N'-acyl thioureas 4a-k with acetylenic esters 5a-b under microwave irradiation and solvent free conditions. Our method, compared to conventional heating conditions has the benefit of higher reaction yield and shorter reaction times. Structural confirmation and characterization of products based on the analytical, chemical, and spectral analysis was confirmed. Cellular investigations showed that the target synthesized thiazolidine-4-ones are toxic and could be used as anticancer agents for MKN-45 gastric adenocarcinoma cells.
Structural and spectral studies of N-(4-chloro)benzoyl-N′ -2-tolylthiourea
Weiqun, Zhou,Kuisheng, Leng,Yong, Zhang,Lu, Lude
, p. 215 - 223 (2003)
The crystal and molecular structure of N-(4-chloro)benzoyl-N′ -2-tolylthiourea (C15H13N2OSCl, Mr = 304.79) is determined by X-ray diffraction. The crystal structure is monoclinic, space group P21In wi
