108641-71-0Relevant academic research and scientific papers
A one-pot method synthesis of α-chloroketone dimethyl acetals
Zhou, Zhong-Shi,Li, Li,He, Xue-Han
, p. 633 - 635 (2013/11/06)
A new one-pot method has been developed for the direct preparation of α-chloroketone dimethyl acetals from ketones using ammonium chloride as the source of chlorine and potassium monoperoxysulfate as the oxidant in the presence of trimethyl orthoformate in methanol at room temperature. Ketones which have electron-withdrawing groups on the aryl rings gave the corresponding a-chloroketone dimethyl acetals in moderate to good yields.
One-step conversion of acetophenones to α-haloacetophenone dimethyl acetals using DCDMH/DBDMH and molecular sieve in methanol
Zhou, Bin,Chen, Zizhan,Zheng, Zubiao,Han, Bingbing,Zou, Xinzhuo
experimental part, p. 1445 - 1453 (2012/04/17)
Using DCDMH/DBDMH as N-halo reagent, piperidine as catalyst, and 4-A molecular sieve as water-removing agent, α-haloacetophenone dimethyl acetals were directly obtained from the solvent of methanol. As to the substrates with electronwithdrawing groups, the conversions were 80-100%. Copyright Taylor & Francis Group, LLC.
EQUILIBRIA INVOLVING HEMIKETAL AND KETAL FORMATION FROM 2-HALOGENOACETOPHENONES
Toeke, Laszlo,Keglevich, Gyoergy,Petnehazy, Imre,Szoelloesy, Aron
, p. 103 - 110 (2007/10/02)
1H-, 13C-NMR, GC measurements and some preparative work have been made to determine the hemiketal and ketal concentrations in mixtures of alcohols and 2-halogenoacetophenones.Equilibrium values for these products, as well as the time required to reach the equilibrium in the absence of acid, were found to be surprisingly high.Comparisons of the values with those of chloroacetone have also been accomplished.
