1086601-89-9Relevant academic research and scientific papers
Design, synthesis, and pharmacological evaluation of a novel series of hormone sensitive lipase inhibitor
Ogiyama, Tomoko,Yamaguchi, Mitsuhiro,Kurikawa, Nobuya,Honzumi, Shoko,Terayama, Koji,Nagaoka, Nobumi,Yamamoto, Yuka,Kimura, Takako,Sugiyama, Daisuke,Inoue, Shin-ichi
, (2017)
HSL inhibition is a promising approach to the treatment of dyslipidemia. As a result of re-optimization of lead compound 2, we identified novel compound 25a exhibiting potent inhibitory activity against HSL enzyme and cell with high selectivity for cholin
4-Aminopyrimidine tetrahydronaphthols: A series of novel vanilloid receptor-1 antagonists with improved solubility properties
Doherty, Elizabeth M.,Retz, Daniel,Gavva, Narender R.,Tamir, Rami,Treanor, James J.S.,Norman, Mark H.
, p. 1830 - 1834 (2008/12/21)
8-(6-(4-(Trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol (4) and analogs (5-10) were shown to be potent inhibitors of human and rat TRPV1 in vitro with increased solubility over our previous series. Synthesis, SAR, and improv
TRIAZOLYL AMINOPYRIMIDINE COMPOUNDS
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Page/Page column 21, (2009/01/20)
The present invention provides triazolyl aminopyrimidine compounds useful in the treatment of cancer.
Vanilloid receptor ligands and their use in treatments
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Page/Page column 47, (2010/11/24)
Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
