108664-58-0

Basic information

• Product Name: 1-(2,4-dichlorophenyl)-2-(1H-pyrazol-1-yl)ethan-1-one
• CAS NO: 108664-58-0
• Molecular Weight: 255.103
• Mol File: 108664-58-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(2,4-dichlorophenyl)-2-(1H-pyrazol-1-yl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4-dichlorophenyl)-2-(1H-pyrazol-1-yl)ethan-1-one(108664-58-0)
• EPA Substance Registry System: 1-(2,4-dichlorophenyl)-2-(1H-pyrazol-1-yl)ethan-1-one(108664-58-0)

Safety Data

• Hazardous Substances Data: 108664-58-0(Hazardous Substances Data)

Upstream product

• 288-13-1 NH-pyrazole 
• 4252-78-2 2,2',4'-trichloroacetophenone 
• 2234-16-4 1-(2,4-dichlorophenyl)ethan-1-one 
• 541-73-1 1,3-Dichlorobenzene 
• 2631-72-3 2,4-dichlorophenacyl bromide 

Downstream Products

• 104941-07-3 1-(2,4-Dichloro-phenyl)-2-pyrazol-1-yl-propenone 

Relevant articles and documents

Novel Tetrazole-Containing Analogues of Itraconazole as Potent Antiangiogenic Agents with Reduced Cytochrome P450 3A4 Inhibition

Itraconazole has been found to possess potent antiangiogenic activity, exhibiting promising antitumor activity in several human clinical studies. The wider use of itraconazole in the treatment of cancer, however, has been limited by its potent inhibition of the drug metabolizing enzyme cytochrome P450 3A4 (CYP3A4). In an effort to eliminate the CYP3A4 inhibition while retaining its antiangiogenic activity, we designed and synthesized a series of derivatives in which the 1,2,4-triazole ring is replaced with various azoles and nonazoles. Among these analogues, 15n with tetrazole in place of 1,2,4-triazole exhibited optimal inhibition of human umbilical vein endothelial cell proliferation with an IC50 of 73 nM without a significant effect on CYP3A4 (EC50 > 20 μM). Similar to itraconazole, 15n induced Niemann-Pick C phenotype (NPC phenotype) and blocked AMPK/mechanistic target of rapamycin signaling. These results suggest that 15n is a promising angiogenesis inhibitor that can be used in combination with most other known anticancer drugs.

Synthesis and Antifungal Activity of a Series of Novel 1,2-Disubstituted Propenones

To find an antifungal agent other than those of the imidazole and triazole series, a new class of 1,2-disubstituted propenones I and II was prepared and tested for antifungal activity.Comparison of the structure-activity relationships showed that the conjugated structure of carbonyl and exomethylene groups in I and II plays an important role in potent antifungal acivity.However, it is noteworthy that compounds 53, 54, and 56, which have a hydroxymethyl or methoxymethyl group instead of an exo-methylene group in I, also showed potent activity.Although many compounds exhibited strong antifungal activity in vitro, none showed activity in vivo of oral efficacy against subacute systemic candidiasis in mice. '