108674-97-1 Usage
Uses
Used in Pharmaceutical Industry:
(3β,5β,15α,16α,17β)-15,16-Dihydro-17-(3-hydroxy-1-propynyl)-3'H-cycloprop[15,16]androsta-6,15-diene-3,5,17-triol is used as an intermediate in the synthesis of various pharmaceutical compounds. One of its primary applications is in the preparation of Drospirenone (D453200), a progestogen hormone used in contraceptives and hormone replacement therapy. Its unique structure allows for the development of new drugs with potential therapeutic benefits.
Used in Chemical Research:
(3β,5β,15α,16α,17β)-15,16-Dihydro-17-(3-hydroxy-1-propynyl)-3'H-cycloprop[15,16]androsta-6,15-diene-3,5,17-triol is also utilized in chemical research for understanding the properties and behavior of complex steroidal structures. It can serve as a model for studying the effects of structural modifications on the biological activity and pharmacological properties of steroidal compounds.
Used in Drug Delivery Systems:
Similar to gallotannin, (3β,5β,15α,16α,17β)-15,16-Dihydro-17-(3-hydroxy-1-propynyl)-3'H-cycloprop[15,16]androsta-6,15-diene-3,5,17-triol may have potential applications in drug delivery systems. Its unique structure could be exploited to develop novel drug carriers or enhance the bioavailability and efficacy of existing pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 108674-97-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,6,7 and 4 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 108674-97:
(8*1)+(7*0)+(6*8)+(5*6)+(4*7)+(3*4)+(2*9)+(1*7)=151
151 % 10 = 1
So 108674-97-1 is a valid CAS Registry Number.
108674-97-1Relevant articles and documents
Aldosterone antagonists. 2. New 7α-(acetylthio)-15,16-methylene spirolactones
Nickisch,Bittler,Laurent,Losert,Casals-Stenzel,Nishino,Schillinger,Wiechert
, p. 1403 - 1409 (2007/10/02)
Some 15,16-methylene derivatives of the aldosterone antagonist spironolactone (1) were synthesized with the purpose of increasing the antialdosterone potency and reducing the endocrinological effects of this standard compound. By introduction of a 1,2-double bond and a 15β,16β-methylene ring in the spironolactone molecule both goals were achieved. In animal studies mespirenone (13) exhibited a threefold-greater antiandosterone potency and less than 10% of the antiandrogenic activity of spironolactone.
