89948-36-7

Basic information

• Product Name: Mespirenone
• CAS NO: 89948-36-7
• Molecular Weight: 426.577
• Mol File: 89948-36-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Mespirenone(CAS DataBase Reference)
• NIST Chemistry Reference: Mespirenone(89948-36-7)
• EPA Substance Registry System: Mespirenone(89948-36-7)

Safety Data

• Hazardous Substances Data: 89948-36-7(Hazardous Substances Data)

Upstream product

• 67372-76-3 7α-(acetylthio)-15β,16β-methylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone 
• 67372-69-4 15β,16β-methylene-3-oxo-17α-pregna-4,6-diene-21,17-carbolactone 
• 82543-15-5 3β,5-dihydroxy-15β,16β-methylene-5β-androst-6-en-17-one 
• 108664-95-5 (3S,5R,8R,9S,10R,13S,14S,15S,16S,17S)-17-(3-Hydroxy-propyl)-10,13-dimethyl-1,3,4,8,9,10,11,12,13,14,15,16,17,20-tetradecahydro-2H-cyclopropa[15,16]cyclopenta[a]phenanthrene-3,5,17-triol 
• 108674-97-1 17α-(3-hydroxypropynyl)-15β,16β-methylene-5β-androst-6-ene-3β,5,17β-triol 

Relevant articles and documents

Aldosterone antagonists. 2. New 7α-(acetylthio)-15,16-methylene spirolactones

Some 15,16-methylene derivatives of the aldosterone antagonist spironolactone (1) were synthesized with the purpose of increasing the antialdosterone potency and reducing the endocrinological effects of this standard compound. By introduction of a 1,2-double bond and a 15β,16β-methylene ring in the spironolactone molecule both goals were achieved. In animal studies mespirenone (13) exhibited a threefold-greater antiandosterone potency and less than 10% of the antiandrogenic activity of spironolactone.