1087161-30-5Relevant academic research and scientific papers
Benzamide derivatives and their constrained analogs as histamine H3 receptor antagonists
Nirogi, Ramakrishna,Shinde, Anil,Tiriveedhi, Vinaykumar,Kota, Laxman,Saraf, Sangram Keshari,Badange, Rajesh Kumar,Mohammed, Abdul Rasheed,Subramanian, Ramkumar,Muddana, Nageshwararao,Bhyrapuneni, Gopinadh,Abraham, Renny
supporting information, p. 655 - 662 (2015/12/31)
A series of 4-(1-substituted piperidin-4-yloxy) benzamides and 6-(1-substituted piperidin-4-yloxy)-3,4-dihydro-2H-isoquinolin-1-one derivatives have been synthesized and tested for their binding affinity towards H3 receptor. Most of these synth
MULTIPLE D2 A(NTA)GONISTS/H3 ANTAGONISTS FOR TREATMENT OF CNS-RELATED DISORDERS
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Page/Page column 54; 56, (2015/05/26)
The present invention relates to compounds compound according to Formula (III); and pharmaceutically acceptable salts, hydrates and solvates thereof. These compounds have D2receptor antagonist/(partial) agonist effects and H3antagonistic effects, pharmaceutical compositions thereof, and methods of using them for application in the prophylaxis or treatment of CNS disorders.
Development of novel 2-[4-(aminoalkoxy)phenyl]-4(3H)-quinazolinone derivatives as potent and selective histamine H3 receptor inverse agonists
Mizutani, Takashi,Nagase, Tsuyoshi,Ito, Sayaka,Miyamoto, Yasuhisa,Tanaka, Takeshi,Takenaga, Norihiro,Tokita, Shigeru,Sato, Nagaaki
scheme or table, p. 6041 - 6045 (2009/06/30)
Novel 2-[4-(aminoalkoxy)phenyl]-4(3H)-quinazolinone derivatives were identified as potent human H3 receptor inverse agonists. After systematic modification of lead 5a, the potent and selective analog 5r was identified. Elimination of hERG K+ channel and human α1A-adrenoceptor activities is the main focus of the present study.
