108718-20-3Relevant academic research and scientific papers
An efficient alkynylation of 4-thiazolidinone with terminal alkyne under C-H functionalisation
Shaikh, Mohammed Umar M.,Mudaliar, Sulochana S.,Chikhalia, Kishor H.
, p. 50780 - 50785 (2016/06/09)
A method of palladium catalysed efficient alkynylation through the cross coupling reaction of terminal alkynes with the slightly more acidic C-H bonds of 4-thiazolidinone has been developed. This method allows the direct introduction of an ethynyl group into the 4-thiazolidinone moiety. Mild reaction conditions involving aerial oxidation and one pot synthesis make this reaction more efficient for the formation of sp3(C)-sp(C) bond.
An efficient and convenient protocol for the synthesis of thiazolidin-4-ones
Ebrahimi,Mobinikhaldei,Eibagi
experimental part, p. 2279 - 2285 (2012/03/26)
Without a catalyst and under solvent-free conditions, 2,3-disubstituted-1, 3- thiazolidin-4-one 5a-j derivatives were synthesized efficiently via the three-component reaction of aryl hydrazide, aromatic aldehyde, and mercaptoacetic acid. All the newly synthesized compounds were confirmed by IR, 1H NMR, and 13C NMR spectroscopy and elemental analysis. Copyright Taylor & Francis Group, LLC.
Thiazolidin-4-one, azetidin-2-one and 1,3,4-oxadiazole derivatives of isonicotinic acid hydrazide: Synthesis and their biological evaluation
Gilani, Sadaf J.,Khan, Suroor A.,Alam, Ozair,Singh, Vijender,Arora, Alka
, p. 1057 - 1067 (2012/02/05)
A series of thiazolidin-4-one (2a-h; 3a-h), azetidin-2-one (4a-h) and 1,3,4-oxadiazole (5a-h) derivatives of isoninicotinic acid hydrazide (INH) were synthesized in order to obtain new compounds with potential anti-inflammatory, analgesic, ulcerogenic and
Synthesis and antimicrobial activity of N-[2-(aryl/substituted aryl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide
Thomas, Asha B.,Nanda, Rabindra K.,Kothapalli, Lata P.,Deshpande, Avinash D.
scheme or table, p. 960 - 968 (2012/03/08)
A series of isonicotinyl hydrazones and their 4-thiazolidinones have been synthesized by condensation of isonicotinic acid hydrazide with various aromatic aldehydes to yield Schiff's bases, followed by the cyclocondensation of Schiff's bases with 2-mercaptoacetic acid to yield their 4-thiazolidinones. The synthesized compounds have been characterized by their elemental, analytical and spectral studies. All these compounds were evaluated for their invitro antimicrobial activity against a spectrum of non-resistant and resistant microbial organisms. These studies proved that compounds 5e,i against B. subtilis; 5e,f,h against B. anthracis; 5g,i against S. aureus showed good activity at lower concentrations. Compounds 5d-5i displayed significant activity against resistant strain of K. pneumonia with minimum inhibitory potency in the concentration range of 2-16 ug/ml.
