108718-62-3Relevant articles and documents
Microwave-mediated pyrazole fluorinations using selectfluor
Sloop, Joseph C.,Jackson, James L.,Schmidt, Robert D.
scheme or table, p. 341 - 345 (2010/08/05)
Microwave-mediated electrophilic fluorinations and a new single-pot condensation en route to ring-fluorinated pyrazoles were examined: chemical equation represented The monofluorination by these methods was successful for a variety of pyrazoles, with yields ranging from 13% to 75%. While electrophilic aromatic fluorination of 3-CF3 pyrazoles proved largely ineffective, development ofa single-pot process overcame this limitation. The microwave-mediated reaction is regioselective; ring fluorination of the heterocycle occurs preferentially over phenyl and alkyl substituents. Alkyl side chain fluorination, when desired, can be modulated by reactant ratios. The single-pot method, which involves acid catalysis by H-TEDA, produces 4-fluoropyrazoles products.
Oxidative Cyclization of Arylhydrazones of Chalcones and Benzalacetones to Pyrazoles by Thianthrene Cation Radical
Kovelesky, Albert C.,Shine, Henry J.
, p. 1973 - 1979 (2007/10/02)
Phenyl-, (p-nitrophenyl)-, and (2,4-dinitrophenyl)hydrazones of chalcone (benzalacetophenone), benzalacetone, and of some of their derivatives undergo oxidative cyclization in reactions with thianthrene cation radical perchlorate.The products are, respect
