109157-01-9Relevant academic research and scientific papers
Pyrazole, pyridine and pyridone synthesis on solid support
Grosche, Philipp,Hoeltzel, Alexandra,Walk, Tilmann B.,Trautwein, Axel W.,Jung, Guenther
, p. 1961 - 1970 (1999)
Versatile solid-phase syntheses of trisubstituted pyrazole carboxylic acids, trisubstituted pyridines and disubstituted pyridones are presented. Pyrazoles are prepared by reaction of polymer bound arylidene- or alkylidene- β-oxo esters with phenylhydrazines. Pyridines result from the Krohnke reaction of immobilised enones with 1-(2-oxo-2-arylethyl)pyridinium salts and ammonium acetate. Pyridones are obtained from polymer bound enones, 1- (methoxycarbonylmethyl)pyridinium bromide and ammonium acetate.
