108771-06-8

Basic information

• Product Name: α-phenyl-4-quinolinemethanol
• Synonyms: α-phenyl-4-quinolinemethanol
• CAS NO: 108771-06-8
• Molecular Weight: 235.285
• Mol File: 108771-06-8.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: α-phenyl-4-quinolinemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: α-phenyl-4-quinolinemethanol(108771-06-8)
• EPA Substance Registry System: α-phenyl-4-quinolinemethanol(108771-06-8)

Safety Data

• Hazardous Substances Data: 108771-06-8(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 108770-98-5 4-(Toluene-4-sulfinyl)-quinoline 
• 4363-93-3 quinoline-4-carboxaldehyde 
• 98-80-6 phenylboronic acid 
• 5632-14-4 4-benzylquinoline 
• 91-22-5 quinoline 
• 3964-04-3 4-bromoquinoline 

Relevant articles and documents

Synthesis and reactivity of lithium tri(quinolinyl)magnesates

2-, 3- and 4-Bromoquinolines were converted to the corresponding lithium tri(quinolinyl)magnesates at -10°C when exposed to Bu3MgLi in THF. The resulting organomagnesium derivatives were quenched with various electrophiles or involved in metal-catalyzed coupling reactions with heteroaryl halides to afford functionalized quinolines.

Transition-Metal Free Chemoselective Hydroxylation and Hydroxylation-Deuteration of Heterobenzylic Methylenes

We developed an approach for direct selective hydroxylation of heterobenzylic methylenes to secondary alcohols avoiding overoxidation to ketones by using a KOBu-t/DMSO/air system. Most reactions could reach completion in several minutes to give hydroxylated products in 41-76% yields. Using DMSO-d6, this protocol resulted in difunctionalization of heterobenzylic methylenes to afford α-deuterated secondary alcohols (>93% incorporation). By employing this method, active pharmaceutical ingredients carbinoxamine and doxylamine were synthesized in two steps in moderate yields.

Palladium-catalyzed 1,2-addition of potassium aryl- and alkenyltrifluoroborates to aldehydes using thioether-imidazolinium carbene ligands

(Chemical Equation Presented) Palladium-catalyzed 1,2-addition of potassium aryl- and alkenyltrifluoroborates to aldehydes using thioether- imidazolinium carbene ligands proceeded readily under aqueous conditions. This process tolerated a diverse range of potassium trifluoroborate salts and aldehydes, giving a variety of carbinol derivatives with good to excellent yields.