108794-64-5

Upstream product

• 67-56-1 methanol 
• 164453-92-3 (2S)-2-hydroxypent-4-enoic acid 
• 922-68-9 Methyl glyoxylate 
• 85116-38-7 (+)-diisopinocampheylallylborane 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 947619-70-7 (S)-2-(4-methoxybenzyloxy)pent-4-enal 
• 911237-04-2 (2S)-2-(4-methoxybenzyloxy)-4-pentenol 
• 603040-45-5 C₁₃H₁₆O₃ 
• 103625-11-2 (2S)-pent-4-ene-1,2-diol 
• 108794-61-2 (4S,5S)-2-Allyloxymethyl-5-phenyl-4,5-dihydro-oxazol-4-ol 

Relevant academic research and scientific papers

Stereoselective Intramolecular Cyclopropanations: Enantioselective Syntheses of 1α,25-Dihydroxyvitamin D3 A-Ring Precursors

Two efficient enantioselective syntheses of an A-ring precursor to 1α,25-dihydroxyvitamin D3 have been developed.The key step in these sequences involves the stereoselective cyclopropanation of a chiral γ-alkoxy-α-diazo-β-keto ester.In one sequence, the 1α-hydroxy group was introduced in the first step by a diastereoselective ene reaction and in the other sequence by use of (S)-malic acid as starting material.Both routes eliminate the need for a SeO2 oxidation.

ASYMMETRIC WITTIG REARRANGEMENT INVOLVING CHIRAL POTASSIUM AZAENOLATES. THE DRAMATIC INFLUENCE OF THE POTASSIUM COUNTERION AND ITS COMPLEXATION WITH 18-CROWN-6

The diastereoface selection is described in the title rearrangement of chiral 2-oxazoline systems either in the absence or the presence of 18-crown-6.The dramatic effects of the K (1+) counterion and its complexation with the crown ether are noted.

A facile synthesis of chiral ω-allyl- and ω-n-propyllactones via asymmetric allylboration of formyl esters with B- allyldiisopinocampheylborane

Asymmetric allylboration of aldehydes containing an adjacent ester group with B-allyldiisopinocampheylborane, followed by hydrolysis and cyclization, provides the corresponding allyl substituted lactones in high yields and ≥92% enantiomeric excess. Hydrogenation of these lactones provides the corresponding propyl substituted lactones without any loss of optical purity.

UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 7 (USP7) MODULATORS AND USES THEREOF

Disclosed herein, inter alia, compounds and methods of use thereof for the modulation of USP7 activity.

E-Selectin Antagonists Modified By Macrocycle Formation to the Galactose

Provided herein are glycomimetic E-selectin antagonist compounds of formula (I)) and pharmaceutical compositions comprising at least one of the same. The compounds of the present disclosure include trisaccharide domain mimics comprising at least one macro

E-SELECTIN ANTAGONISTS MODIFIED BY MACROCYCLE FORMATION TO THE GALACTOSE

Provided herein are glycomimetic E-selectin antagonist compounds of formula (I)) and pharmaceutical compositions comprising at least one of the same. The compounds of the present disclosure include trisaccharide domain mimics comprising at least one macro