1088-32-0

Basic information

• Product Name: 5(4H)-Isoxazolone, 3-phenyl-4-(phenylmethylene)-
• CAS NO: 1088-32-0
• Molecular Formula: C16H11NO2
• Molecular Weight: 249.269
• Mol File: 1088-32-0.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 5(4H)-Isoxazolone, 3-phenyl-4-(phenylmethylene)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5(4H)-Isoxazolone, 3-phenyl-4-(phenylmethylene)-(1088-32-0)
• EPA Substance Registry System: 5(4H)-Isoxazolone, 3-phenyl-4-(phenylmethylene)-(1088-32-0)

Safety Data

• Hazardous Substances Data: 1088-32-0(Hazardous Substances Data)

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 932-90-1 Benzaldoxime 
• 100-52-7 benzaldehyde 
• 1076-59-1 3-phenyl-4H-isoxazol-5-one 
• 127916-11-4 ethyl bezoylacetate oxime 
• 7713-79-3 3-phenyl-5-isoxazolone 

Downstream Products

• 72705-83-0 4-benzyl-3-phenylisoxazol-5(4H)-one 
• 136320-21-3 2,7-Diphenyl-1,5-dioxa-6-aza-spiro[2.4]hept-6-en-4-one 
• 53870-19-2 methyl 3-(4,5-dihydro-5-oxo-3-phenylisoxazol-4-yl)-3-phenylpropanoate 
• 21136-48-1 1,3-diphenylhex-5-en-1-one 
• 109012-83-1 dimethyl 2-(3-oxo-1,3-diphenylpropyl)malonate 
• 220044-16-6 1,3,5-triphenylpentane-1,4-dione 
• 494844-63-2 (hex-5-en-1-yne-1,3-diyl)dibenzene 

Relevant articles and documents

Facile and expedient synthesis of α,β-unsaturated isoxazol-5(4H)-ones under mild conditions

Abstract: It was found that nano-SiO2–H2SO4 was catalyzed by the three-component cyclocondensation of aryl/heteroaryl aldehydes, hydroxylamine hydrochloride, and β-ketoesters toward the synthesis of α,β-unsaturated?isoxazol-5(4H)-ones under green conditions. The reaction yielded the corresponding heterocycles at room temperature in relatively shorter reaction times. It merits mentioning that the mild conditions allow the synthesis of several α,β-unsaturated?isoxazol-5(4H)-ones using this method. In this study, some new derivatives of isoxazolones were also synthesized and characterized. It is efficient, clean, simple, safe, and ecologically friendly. This straightforward method is cost-effective and requires no preparation of reactants. The three-component annulation was performed without using energy sources, for example, heat, ultrasound wave, and microwave irradiation. Graphic abstract: [Figure not available: see fulltext.].

One-pot green synthesis of isoxazol-5(4H)-one derivatives using Dowex1-x8OH in water

4-(Arylmethylidene)-3-methylisoxazol-5(4H)-ones and 4-(arylmethylidene)-3-phenylisoxazol-5(4H)-ones were synthesized in a one-pot three-component procedure in the presence of Dowex1-x8OH as catalyst in water. The products were obtained in high yields (90-

Michael Addition of Soft Carbon Nucleophiles to Alkylidene Isoxazol-5-ones: A Divergent Entry to β-Branched Carbonyl Compounds

A novel, divergent strategy toward the synthesis of β-branched (and linear) carbonyl compounds is developed by taking advantage of alkylidene isoxazol-5-ones as key building blocks. The yields obtained range from good to excellent, therefore making the described methods attractive options for building such molecules. (Chemical Equation).