108817-35-2

Usage

Uses

Used in Pharmaceutical Industry:
1-Chlorocyclopropane-1-carboxylic acid is used as a synthetic intermediate for the development of various pharmaceuticals. Its unique structure allows for the creation of new drug molecules with potential therapeutic applications, contributing to the advancement of medicine.
Used in Agricultural Chemical Industry:
In the agricultural sector, 1-chlorocyclopropane-1-carboxylic acid is utilized as a precursor in the synthesis of agricultural chemicals. Its involvement in the production of these chemicals aids in enhancing crop protection and improving overall agricultural productivity.
Used in Organic Synthesis:
1-Chlorocyclopropane-1-carboxylic acid is employed as a versatile building block in organic synthesis. Its reactivity and structural features make it suitable for the preparation of a wide range of organic compounds, expanding the scope of chemical research and development.

Upstream product

• 4023-34-1 cyclopropanecarboxylic acid chloride 

Downstream Products

• 59-67-6 nicotinic acid 
• 1614262-52-0 (2,3,4,5,6-pentafluorophenyl) 1-chlorocyclopropanecarboxylate 
• 73492-25-8 1-chlorocyclopropanecarboxylic acid chloride 
• 1594129-49-3 N-((S)-1-(4-((R)-1-(4-(cyclopropylmethoxy)phenyl)pyrrolidin-3-yloxy)phenyl)ethyl)cyclopropanecarboxamide 

Relevant academic research and scientific papers

Kinetics of Cyclopropyl Radical Reactions. 3. Study of Some 1-Substituted Cyclopropyl Radicals by EPR Spectroscopy. The Inversion Barrier for 1-Methylcyclopropyl

The 1-methyl-, 1-ethoxy-, and 1-chlorocyclopropyl radicals have been observed by low-temperature EPR spectroscopy in "frozen" configurations in which the ring hydrogens that are syn and anti to the unpaired elecron's orbital have different hyperfine splittings.The aH(syn)/aH(anti) ratios are 1.5 (CH3), 1.8 (EtO), and 1.9 (Cl), all considerably lower than the ratio of ca. 3.3 found by Kawamura et al. for methyl-substituted 1-fluorocyclopropyl radicals.The out-of-plane angles of the 1-substituent have been calculated from measured a13Cα values to be 22.5 deg (cyclopropyl), 22.9 deg (CH3), 29.1 deg (EtO), and 5.8 deg (MeSi).These angles are considerably smaller than those that have been calculated for some of these radicals by ab initio and other methods.Variable-temperature EPR spectroscopy on 1-methylcyclopropyl yields the following Arrhenius equation for its inversion: log (kinv/s-1) = (13.1 +/- 0.3) - (3.1 +/- 0.2)/2.3RT kcal/mol.For 1-ethoxycyclopropyl the rate constant for rotation about the .C-OEt bond can be represented by log (krot/s-1) = (12.5 +/- 0.2) - (5.8 +/- 0.2)/2.3RT.The barrier to inversion of this radical is >/= 9 kcal/mol.The 1-chlorocyclopropyl radical could only be observed at very low temperatures.