108837-20-3Relevant articles and documents
7-Hydroxy-4'-methoxyflavanone
Kendi, Engin,Oezbey, Sueheyla,Ertan, Rahmiye,Fun, Hoong-Kun,Yip, Boon-Chuan
, p. 1442 - 1444 (1995)
The γ-pyrone ring of the title molecule adopts the C2-sofa conformation; the C2 and C3 atoms show disorder.The 2-phenyl substituent is twisted out of the benzo-γ-pyrone
Glycolytic inhibition and antidiabetic activity on synthesized flavanone scaffolds with computer aided drug designing tools
Kiruthiga, Natarajan,Saravanan, Govindaraj,Selvinthanuja, Chellappa,Sivakumar, Thangavel,Srinivasan, Kulandaivel
, p. 574 - 592 (2021/09/30)
Background: Diabetes mellitus is a challengeable metabolic disorder that leads to a group of complications when the HbA1c level is not maintained. Most of the existing drugs avail-able in the market in long-term use may lead to serious adverse effects. He
Design, Synthesis, and Potential Antidepressant-like Activity of 7-prenyloxy-2,3-dihydroflavanone Derivatives
Zhen, Xing-Hua,Quan, Ying-Chun,Peng, Zhou,Han, Yan,Zheng, Zhou-Jun,Guan, Li-Ping
, p. 858 - 866 (2016/05/19)
A series of 7-prenyloxy-2, 3-dihydroflavanone derivatives were synthesized and screened for their antidepressant-like activity. Among them, it was observed that compounds 5j and 5k were found to be the most antidepressant-like activity. In addition, it was found that compounds 5j and 5k significantly increased the concentrations of the main neurotransmitters 5-HT and NE in the hippocampus, hypothalamus, and cortex. Compounds 5j and 5k also significantly increased the contents of 5-HIAA in the hippocampus and cortex, shut down 5-HT metabolism compared with mice treated with stress vehicle. These results suggested that compounds 5j and 5k displayed potent antidepressant-like properties that were mediated via neurochemical systems.