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Ethane-1,2-diylbis(phenylphosphinic acid), also known as P,P''-Diphenylethylenediphosphinic acid, is an organic compound with the molecular formula C16H15O2P2. It is characterized by its phosphinic acid functional groups attached to a central ethane-1,2-diyl group. This molecule has the potential to interact with proteins and modulate their functions due to its unique structure and properties.

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  • 1089-77-6 Structure
  • Basic information

    1. Product Name: ethane-1,2-diylbis(phenylphosphinic acid)
    2. Synonyms: ethane-1,2-diylbis(phenylphosphinic acid);ethane-P,P'-diphenyl-1,2-diphosphinic acid
    3. CAS NO:1089-77-6
    4. Molecular Formula: C14H16O4P2
    5. Molecular Weight: 310.221962
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1089-77-6.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 674.5°C at 760 mmHg
    3. Flash Point: 361.7°C
    4. Appearance: /
    5. Density: 1.34g/cm3
    6. Vapor Pressure: 4.1E-19mmHg at 25°C
    7. Refractive Index: 1.587
    8. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    9. Solubility: N/A
    10. CAS DataBase Reference: ethane-1,2-diylbis(phenylphosphinic acid)(CAS DataBase Reference)
    11. NIST Chemistry Reference: ethane-1,2-diylbis(phenylphosphinic acid)(1089-77-6)
    12. EPA Substance Registry System: ethane-1,2-diylbis(phenylphosphinic acid)(1089-77-6)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1089-77-6(Hazardous Substances Data)

1089-77-6 Usage

Uses

Used in Pharmaceutical Industry:
Ethane-1,2-diylbis(phenylphosphinic acid) is used as a protein-protein interaction inhibitor for the treatment of cystic fibrosis. It specifically binds to ΔF508-CFTR-NBD1, a mutant form of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, which is associated with the most common form of the disease. By inhibiting the protein-protein interactions, ethane-1,2-diylbis(phenylphosphinic acid) can potentially improve the function of the mutant CFTR protein and alleviate the symptoms of cystic fibrosis.
Used in Chemical Research:
Ethane-1,2-diylbis(phenylphosphinic acid) can also be utilized in chemical research as a reagent or a building block for the synthesis of more complex molecules. Its unique structure and functional groups make it a valuable tool for exploring new chemical reactions and developing novel compounds with potential applications in various fields, such as materials science, pharmaceuticals, and agrochemicals.

Check Digit Verification of cas no

The CAS Registry Mumber 1089-77-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,8 and 9 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1089-77:
(6*1)+(5*0)+(4*8)+(3*9)+(2*7)+(1*7)=86
86 % 10 = 6
So 1089-77-6 is a valid CAS Registry Number.
InChI:InChI=1/C14H16O4P2/c15-19(16,13-7-3-1-4-8-13)11-12-20(17,18)14-9-5-2-6-10-14/h1-10H,11-12H2,(H,15,16)(H,17,18)

1089-77-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[hydroxy(phenyl)phosphoryl]ethyl-phenylphosphinic acid

1.2 Other means of identification

Product number -
Other names P,P'-Diphenyl-P,P'-aethandiyl-bis-phosphinsaeure

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1089-77-6 SDS

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