108907-44-4

Usage

Uses

Used in Health and Wellness Applications:
(-)-ECG-4''-O-ME is used as a health-promoting agent for its potential ability to protect cells from oxidative stress and exhibit anti-inflammatory properties. These characteristics suggest that it may contribute to overall well-being and support the body's natural defenses against harmful free radicals and inflammation.
Used in Cardiovascular Disease Prevention:
(-)-ECG-4''-O-ME is being investigated for its potential role in preventing cardiovascular diseases. Its antioxidant properties may help reduce the risk of heart-related conditions by protecting the cardiovascular system from oxidative damage and inflammation.
Used in Cancer Prevention:
(-)-ECG-4''-O-ME is also being studied for its potential role in preventing certain types of cancer. (-)-ECG-4''-O-ME's antioxidant and anti-inflammatory properties may contribute to a reduced risk of cancer development, although more research is needed to fully understand its effects and potential applications in this area.

Upstream product

• 485-80-3 S-adenosyl-L-methionine 
• 863-03-6 (-)-epicatechin gallate 
• 1186527-08-1 3,5-di(2-nitrobenzenesulfonyloxy)-4-methoxybenzoic acid 
• 1186527-20-7 (2R,3R)-2-(3,4-bis(2-nitrophenylsulfonyloxy)phenyl)-3-hydroxychromane-5,7-diyl bis(2-nitrobenzenesulfonate) 
• 1186527-22-9 (2R,3R)-2-(3,4-bis(2-nitrophenylsulfonyloxy)phenyl)-5,7-bis(2-nitrophenylsulfonyloxy)chroman-3-yl 4-methoxy-3,5-bis(2-nitrophenylsulfonyloxy)benzoate 
• 901125-29-9 (-)-(2R,3R)-cis-5,7-bis(benzyloxy)-2-[3',4'-bis(benzyloxy)-phenyl]chroman-3-yl 3'',5''-dibenzyloxy-4''-methoxybenzoate 
• 19859-89-3 3,5-bis(benzyloxy)-4-methoxybenzoyl chloride 
• 19859-90-6 [3,5-bis(benzyloxy)-4-methoxyphenyl]methanol 

Downstream Products

• 108907-47-7 3,5-Diethoxy-4-methoxy-benzoic acid (2R,3R)-2-(3,4-diethoxy-phenyl)-5,7-diethoxy-chroman-3-yl ester 
• 490-46-0 (2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-1[2H]-benzopyran-3,5,7-triol 

Relevant academic research and scientific papers

Methylation of tea catechins by rat liver homogenates.

Methylation of (-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECg), and (-)-epigallocatechin gallate (EGCg) was carried out with a rat liver homogenate and S-adenosyl-L-methionine. A structural analysis of the reaction products by MS and NMR showed

Syntheses of methylated catechins and theaflavins using 2-nitrobenzenesulfonyl group to protect and deactivate phenol

An efficient and versatile synthetic method for labile polyphenols was established using 2-nitrobenzenesulfonate (Ns) as a protecting group for phenol. This methodology provides regio-and stereoselective access to a range of methylated catechins, such as methylated epigallocatechin gallates, that are not readily available from natural sources. In addition, biomimetic synthesis of theaflavins from catechins was accomplished using Ns protection to minimize undesired side reactions of electron-rich aromatic rings during oxidation, enabling construction of the complex benzotropolone core in a single-step oxidative coupling reaction. Availability of these compounds will aid detailed structure-biological activity relationship studies of catechins.

Regioselective synthesis of methylated epigallocatechin gallate via nitrobenzenesulfonyl (Ns) protecting group

Regioselective synthesis of methylated epigallocatechin gallate from epigallocatechin was accomplished using a 2-nitrobenzenesulfonyl (Ns) group as a protecting group for phenols. This methodology provided several methylated catechins, which are naturally

Regiospecific and enantioselective synthesis of methylated metabolites of tea catechins

The regiospecific and enantioselective syntheses of various methylated regioisomers of epicatechin gallate (EGC) and epigallocatechin gallate (EGCG) have been achieved.