4969-01-1

Basic information

• Product Name: 1,4-dioxaspiro[4.5]decan-9-one
• Synonyms: 1,4-dioxaspiro[4.5]decan-9-one;1,4-Dioxaspiro[4.5]decan-7-one
• CAS NO: 4969-01-1
• Molecular Formula: C₈H₁₂O₃
• Molecular Weight: 156.18
• Mol File: 4969-01-1.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 261.4°C at 760 mmHg
• Flash Point: 102.5°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 0.0116mmHg at 25°C
• Refractive Index: 1.489
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 1,4-dioxaspiro[4.5]decan-9-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-dioxaspiro[4.5]decan-9-one(4969-01-1)
• EPA Substance Registry System: 1,4-dioxaspiro[4.5]decan-9-one(4969-01-1)

Safety Data

• Hazardous Substances Data: 4969-01-1(Hazardous Substances Data)

Usage

Uses

1,4-Dioxaspiro[4,5]decan-7-one is a chemical reagent used in the preparation of rhodesain inhibitors which combat trypanosoma brucei parasites.

InChI:InChI=1/C8H12O3/c9-7-2-1-3-8(6-7)10-4-5-11-8/h1-6H2

Upstream product

• 504-02-9 1,3-cylohexanedione 
• 19770-37-7 6,7-epoxy-1,4-dioxaspiro<4,5>decane 
• 1728-15-0 (R,S)-6-bromo-1,4-dioxaspiro<4.5>decane 
• 62906-51-8 2-Brom-3-hydroxycyclohexanon-ethylenketal 
• 1004-58-6 1,4-dioxa-spiro[4.5]dec-6-ene 
• 159888-59-2 2-bromo-3-oxo-cyclohexanone ethylene acetal 
• 107-21-1 ethylene glycol 
• 73223-83-3 1,4-dioxaspiro[4,5]decan-9-ol 

Downstream Products

• 25017-78-1 3-cyano-2-cyclohexenone 
• 65093-64-3 ethyl 2-(3-oxocyclohex-1-en-1-yl)acetate 
• 73223-83-3 1,4-dioxaspiro[4,5]decan-9-ol 
• 108932-40-7 3-(3'-Thienyl)-2-cyclohexen-1-one 

Relevant articles and documents

Drug delivery to the malaria parasite using an arterolane-like scaffold

Antimalarial agents artemisinin and arterolane act via initial reduction of a peroxide bond in a process likely mediated by ferrous iron sources in the parasite. Here, we report the synthesis and antiplasmodial activity of arterolane-like 1,2,4-trioxolanes specifically designed to release a tethered drug species within the malaria parasite. Compared with our earlier drug delivery scaffolds, these new arterolane-inspired systems are of significantly decreased molecular weight and possess superior metabolic stability. We describe an efficient, concise and scalable synthesis of the new systems, and demonstrate the use of the aminonucleoside antibiotic puromycin as a chemo/biomarker to validate successful drug release in live Plasmodium falciparum parasites. Together, the improved drug-like properties, more efficient synthesis, and proof of concept using puromycin, suggests these new molecules as improved vehicles for targeted drug delivery to the malaria parasite.

SPIROCYCLIC TETRAHYDROQUINAZOLINES

Provided are compounds represented by Formula I, wherein R3, A, A1, A2, A3, E, E1, E2, L, Q, Z, and (aa) are as defined in the specification, and the pharmaceutically acceptable salts and solvates thereof. Compounds of Formula (I) are KRAS inhibitors and are thus useful to treat cancer and other diseases.

Ring-opening reactions of donor-acceptor cyclopropanes with cyclic ketals and thiol ketals

1,3-Cyclohexandione derived cyclic ketals and thiol ketals were used as O- and S-nucleophiles, respectively, for the ring opening of donor-acceptor cyclopropanes catalyzed by Cu(OTf)2 and a series of functionalized alkylene glycol diethers and dithiol diethers were obtained in good to high yields under mild conditions. This journal is

Stereoelectronic Model to Explain Highly Stereoselective Reactions of Seven-Membered-Ring Oxocarbenium-Ion Intermediates

Nucleophilic attack on seven-membered-ring oxocarbenium ions is generally highly stereoselective. The preferred mode of nucleophilic attack forms the product in a conformation that minimizes transannular interactions, thus leading to different stereoselectivity as compared to that of reactions involving six-membered-ring oxocarbenium ions.