108932-50-9

Upstream product

• 10313-60-7 3,4-dimethoxyphenylacetyl chloride 
• 100-52-7 benzaldehyde 
• 74-89-5 methylamine 
• 103-67-3 benzyl-methyl-amine 

Downstream Products

• 17105-71-4 N-methyl-N-benzylformamide 
• 29524-30-9 dichloro-acetic acid-(benzyl-methyl-amide) 
• 93-07-2 Veratric acid 
• 135182-05-7 4-(3,4-Dimethoxyphenyl)-2-methyl-1,4-dihydro-3(2H)-isoquinolinone 
• 135182-12-6 N-Benzyl-N-methyl-α-acetoxy-α-(3,4-dimethoxyphenyl)acetamide 

Relevant academic research and scientific papers

A new synthesis of N-substituted-1,2,3,4-tetrahydro-4-phenylisoquinolin-3-ones

1,2,3,4-Tetrahydro-4-phenylisoquinolin-3-ones 3 are obtained from appropriate N,N-disubstituted phenylacetamides 1, using lead tetraacetate (LTA) as oxidant and Lewis or proton acids as cyclizing agents. The methods for this conversion could be one stage (method B or C), or two stages (method A). The latter method was particularly developed to explain the mechanism of the reaction.

Synthesis of 4-aryl-1,4-dihydro-3(2H)-isoquinolinones by oxidative cyclization of N-benzylaraylacetamides

4-Aryl-1,4-dihydro-3(2H)-isoquinolinones are obtained by oxidative cyclization of N-benzyl-N-alkylarylacetamides with lead tetraacetate in acetic acid/trifluoroacetic acid.