108953-96-4Relevant academic research and scientific papers
Organocatalytic Enantioselective Decarboxylative Protonation Reaction of Meldrum's Acid Derivatives under PTC Conditions
Legros, Fabien,Martzel, Thomas,Brière, Jean-Fran?ois,Oudeyer, Sylvain,Levacher, Vincent
supporting information, p. 1975 - 1983 (2018/05/15)
An original organocatalyzed enantioselective protonation sequence of a transient quaternary ammonium enolate species has been developed by starting from readily available disubstituted Meldrum's acid derivatives and phenols. Under phase-transfer-catalytic (PTC) conditions, chiral nonracemic 2-aryl propionic ester derivatives were obtained in good isolated yields with enantioselectivities up to 70 % ee. The usefulness of the approach was demonstrated by the synthesis of enantioenriched (S)-ibuprofen.
