30148-23-3

Basic information

• Product Name: 2-trichloroacetyl-1-methylimidazole
• Synonyms: 2-trichloroacetyl-1-methylimidazole
• CAS NO: 30148-23-3
• Molecular Weight: 227.477
• Mol File: 30148-23-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: 83-84 °C
• Boiling Point: 272.3±50.0 °C(Predicted)
• Density: 1.56±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 2-trichloroacetyl-1-methylimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-trichloroacetyl-1-methylimidazole(30148-23-3)
• EPA Substance Registry System: 2-trichloroacetyl-1-methylimidazole(30148-23-3)

Safety Data

• Hazardous Substances Data: 30148-23-3(Hazardous Substances Data)

Usage

Uses

1-?Methyl-?2-?(trichloroacetyl)?imidazole is a useful reactant in the synthesis of pyrrole-?imidazole polyamide oligomers and DNA-?binding Py-?Im polyamides.

Upstream product

• 616-47-7 1-methyl-1H-imidazole 
• 76-02-8 trifluoroacetyl chloride 

Downstream Products

• 120095-64-9 2,2,2-trichloro-1-(1-methyl-4-nitro-1H-imidazol-2-yl)ethan-1-one 
• 120095-65-0 2,2,2-Trichloro-1-(1-methyl-5-nitro-1H-imidazol-2-yl)-ethanone 
• 129601-50-9 N-<5-<<(3,3-dimethylaminopropyl)amino>carbonyl>-1-methyl-1H-pyrrol-3-yl>-4-<<<1-methyl-1H-imidazol-2-yl>carbonyl>amino>-1-methyl-1H-pyrrole-2-carboxamide 
• 109012-23-9 ethyl 1-methyl-4-nitroimidazole-2-carboxylate 
• 128293-64-1 4-[(tert-butoxycarbonyl)amino]-1-methylimidazole-2-carboxylic acid 
• 179983-49-4 tert-butyl 4-nitro-N-methyl-1H-imidazole-2-carboxylate 
• 162085-97-4 methyl 4-amino-1-methyl-1H-imidazole-2-carboxylate 
• 128293-65-2 benzyl 4-((tert-butoxycarbonyl)amino)-1-methyl-1H-imidazole-2-carboxylate 
• 252206-28-3 4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-1-methyl-1H-imidazole-2-carboxylic acid 

Relevant articles and documents

An improved synthesis of 1-methyl-2-trichloroacetylimidazole

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4-Methyltrityl-Protected Pyrrole and Imidazole Building Blocks for Solid Phase Synthesis of DNA-Binding Polyamides

DNA-binding polyamides are synthetic oligomers of pyrrole/imidazole units with high specificity and affinity for double-stranded DNA. To increase their synthetic diversity, we report a mild methodology based on 4-methyltrityl (Mtt) solid phase peptide synthesis (SPPS), whose building blocks are more accessible than the standard Fmoc and Boc SPPS ones. We demonstrate the robustness of the approach by preparing and studying a hairpin with all precursors. Importantly, our strategy is orthogonal and compatible with sensitive molecules and could be readily automated.

AMIDE COMPOUND

A compound represented by the formula (I) wherein ring Cy1 is a 5-membered aromatic heterocycle optionally further substituted besides a group represented by -A-B, ring Cy2 is an optionally substituted benzene ring, ring Cy3 is an optionally substituted 5-membered aromatic heterocycle, ring Cy4 is an optionally substituted 6-membered aromatic ring, A is -CONRa- or -NRaCO-, Ra is a hydrogen atom or a substituent, B is a hydrogen atom or an optionally substituted C1-6 alkyl-group, X is an optionally substituted C1-2 alkylene, -Y-, -Y-CH2- or - CH2-Y-, Y is an oxygen atom, -NRb- or -S(O)m-, Rb is a hydrogen atom or a substituent, and m is 0, 1 or 2, provided that N-methyl-4-[2-[3,4,5-trimethoxyphenyl)amino]-1,3-benzoxazol-7-yl]thiophene-2-carboxamide is excluded, or a salt thereof, has an agonistic action on GPR52, and is useful as an agent for the prophylaxis or treatment of schizophrenia and the like.