109013-66-3Relevant academic research and scientific papers
Regiospecific synthesis of 2,3-disubstituted-L-histidines and histamines
Narayanan, Sanju,Vangapandu, Suryanarayana,Jain, Rahul
, p. 1133 - 1136 (2001)
Regiospecific synthesis of 2,3-disubstituted-L-histidines and 2,3-disubstituted histamines starting from L-histidine methyl ester and histamine is reported. The key step involves homolytic free radical alkylation via silver catalyzed oxidative decarboxyla
Phenacyl-Directed Alkylation of Imidazoles: A New Regiospecific Synthesis of 3-Substituted L-Histidines
Chivikas, Cleo J.,Hodges, John C.
, p. 3591 - 3594 (2007/10/02)
A new strategy for regiospecific imidazole alkylation of suitably protected histidines is described wherein a phenacyl group serves as a protecting group of the distal imidazole nitrogen atom.Alkylation of N-BOC-1-phenacyl-L-histidine methyl ester at N(3)
