1090340-67-2Relevant articles and documents
Iron-catalyzed C-H/N-H activation by triazole guidance: Versatile alkyne annulation
Cera,Haven,Ackermann
, p. 6460 - 6463 (2017/07/10)
Iron-catalyzed C-H/N-H functionalizations were achieved by the aid of modular triazole amides. The alkyne annulation allowed for the expedient synthesis of valuable isoquinolone scaffolds with high levels of chemo-, site- and regio-selectivities.
Multifunctional multivalency: A focused library of polymeric cholera toxin antagonists
Tran, Huu-Anh,Kitov, Pavel I.,Paszkiewicz, Eugenia,Sadowska, Joanna M.,Bundle, David R.
experimental part, p. 3658 - 3671 (2011/06/19)
Structural pre-organization of the multivalent ligands is important for successful interaction with multimeric proteins. Polymer-based heterobifunctional ligands that contain pendant groups prearranged into heterodimers can be used to probe the active site and surrounding area of the receptor. Here we describe the synthesis and activities of a series of galactose conjugates on polyacrylamide and dextran. Conjugation of a second fragment resulted in nanomolar inhibitors of cholera toxin, while the galactose-only progenitors showed no detectable activity.