1090477-72-7

Upstream product

• 4410-31-5 (RS)-mandelamide 
• 371-40-4 4-fluoroaniline 
• 1046786-81-5 N-(4-fluorolphenyl)-2-oxo-2-phenylacetamide 
• 611-73-4 Benzoylformic acid 
• 98-86-2 acetophenone 

Downstream Products

• 849529-82-4 2-((4-fluorophenyl)amino)-1-phenylethan-1-ol 

Relevant academic research and scientific papers

“On-water” reduction of α-keto amide by Hantzsch ester: A chemoselective catalyst- and additive-free way to α-hydroxy amide

An efficient and practical method for chemoselective “on-water” reduction of α-keto amide by Hantzsch ester without using any catalysts and additives was developed. Control experiments indicated that the intramolecular hydrogen bond of α-keto amide was cr

Ru-g-C3N4as a highly active heterogeneous catalyst for transfer hydrogenation of α-keto amide into β-aminol or α-hydroxyl amide

This work reports a sustainable route for the catalytic transfer hydrogenation (CTH) of α-keto amide into β-aminol via an efficient heterogeneous catalyst wherein ruthenium is incorporated on an active graphite sheet of a carbon nitride support (Ru-g-C3N4). Other different metals like Ni or Pd were also screened with the same support but none of them showed efficient activity. Although, partial hydrogenation of ketone to alcohol has also been observed based on the optimization of the reaction parameters using all of the above catalysts. The catalyst has been characterized using field emission gun scanning electron microscopy (FEG-SEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), infra-red (IR) spectroscopy and thermogravimetric analysis (TGA). Furthermore, the catalyst has been recycled and further characterized and does not show any significant changes in its reactivity for the CTH process. Ru-g-C3N4 as a recyclable heterogenous catalyst has been used for the first time for the CTH of α-keto amide into β-aminol, making the process sustainable because economical and environmentally benign isopropyl alcohol is used as a solvent system. The proposed catalytic system shows a wide scope of substrates for α-hydroxyamide and β-aminol derivatives, which were confirmed from 1H and 13C-NMR. This journal is

Method for preparing alpha-hydroxy amide by selective reduction of ketone carbonyl group of alpha-ketoamide

The invention relates to a method for preparing alpha-hydroxy amide by selective reduction of a ketone carbonyl group of alpha-ketoamide. The method comprises the following steps: performing a reaction on the alpha-ketoamide and a formate in an organic so

Catalyst- and Additive-Free Chemoselective Transfer Hydrogenation of α-Keto Amides to α-Hydroxy Amides by Sodium Formate

A catalyst- and additive-free chemoselective transfer hydrogenation of α-keto amides to α-hydroxy amides is easily achieved by using sodium formate as a hydrogen source. The utility of this method is demonstrated by gram-scale synthesis and transformation of the resultant α-hydroxy amides into polysubstituted acetamides and 2-arylindole derivatives. Control experiments suggest that the NH group of α-keto amides is crucial for the chemoselective reduction through the formation of hydrogen bonds.

Method for preparing alpha-hydroxyamide by reducing alpha-keto amides

The invention relates to a method for preparing alpha-hydroxyamide. Alpha-keto amides and inorganic alkali react in an organic solvent for 6-18 hours at 110-150 DEG C, and the alpha-hydroxyamide is obtained through reduction. According to the preparation

Efficient copper(II)-catalyzed transamidation of non-activated primary carboxamides and ureas with amines

Amid(e) them all: Primary carboxamides and ureas react with aromatic and aliphatic amines in the presence of a copper catalyst to give a wide range of functionalized amides (see scheme). Copyright