109069-76-3

Basic information

• Product Name: 3,5-dimethoxy-2-nitrobenzoyl chloride
• Synonyms: 3,5-dimethoxy-2-nitrobenzoyl chloride
• CAS NO: 109069-76-3
• Molecular Weight: 245.619
• Mol File: 109069-76-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3,5-dimethoxy-2-nitrobenzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-dimethoxy-2-nitrobenzoyl chloride(109069-76-3)
• EPA Substance Registry System: 3,5-dimethoxy-2-nitrobenzoyl chloride(109069-76-3)

Safety Data

• Hazardous Substances Data: 109069-76-3(Hazardous Substances Data)

Upstream product

• 1132-21-4 3,5-dimethoxybenzoic acid 
• 76746-30-0 2-Nitro-3,5-dimethoxybenzoate de methyle 
• 2150-37-0 methyl 3,5-dimethoxybenzoate 
• 113884-71-2 Acide 2-nitro-3,5-dimethoxybenzoique 

Downstream Products

• 1075748-44-5 1,2-diamino-3,5-dimethoxybenzene 
• 192696-43-8 3,5-Dimethoxy-2-nitrobenzenamine 
• 131653-13-9 5-(3,5-Dimethoxy-2-nitro-benzyl)-6-methyl-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinolin-6-ium; iodide 
• 131653-16-2 5-(3,5-Dimethoxy-2-nitro-benzyl)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline 
• 131653-14-0 5-[1-(3,5-Dimethoxy-2-nitro-phenyl)-meth-(Z)-ylidene]-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline 
• 131653-15-1 2,4-Dimethoxy-6-(6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-ylmethyl)-phenylamine 
• 126893-22-9 1-(2-nitro-3,5-dimethoxy-benzyl)-6,7-methylenedioxy-3,4-dihydroisoquinoline 
• 126893-21-8 N-(2-Benzo[1,3]dioxol-5-yl-ethyl)-2-(3,5-dimethoxy-2-nitro-phenyl)-acetamide 
• 102652-89-1 3,5-dimethoxy-2-nitroacetophenone 
• 23042-76-4 2-amino-3,5-dimethoxyacetophenone 
• 126893-26-3 2-Nitro-3,5-dimethoxy-ω-diazoacetophenone 

Relevant articles and documents

Synthesis and biological evaluation of novel analogues of the pan class i phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(Difluoromethyl)-1-[4,6-di(4- morpholinyl)-1,3,5-triazin-2-yl]-1 H -benzimidazole (ZSTK474)

A structure-activity relationship (SAR) study of the pan class I PI 3-kinase inhibitor 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2- yl]-1H-benzimidazole (ZSTK474) identified substitution at the 4 and 6 positions of the benzimidazole ring as having significant effects on the potency of substituted derivatives. The 6-amino-4-methoxy analogue displayed a greater than 1000-fold potency enhancement over the corresponding 6-aza-4-methoxy analogue against all three class Ia PI 3-kinase enzymes (p110α, p110β, and p110δ) and also displayed significant potency against two mutant forms of the p110α isoform (H1047R and E545K). This compound was also evaluated in vivo against a U87MG human glioblastoma tumor xenograft model in Rag1 -/- mice, and at a dose of 50 mg/kg given by ip injection at a qd ?- 10 dosing schedule it dramatically reduced cancer growth by 81% compared to untreated controls.

Alkaloids from Annonaceae 93. First synthesis of a meta-disubstituted aporphine

The synthesis of a new aporphinoid alkaloid, substituted on the 9 and 11 positions, is reported.An unexpected reactivity has been observed for several intermediates.It has been attributed to the position of the methoxy groups with regard to the nitro group.