109152-86-5Relevant academic research and scientific papers
PARTICLES, COMPOSITIONS, AND METHODS FOR OPHTHALMIC AND/OR OTHER APPLICATIONS
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Paragraph 0187, (2019/04/11)
This disclosure relates to particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications.
Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; The identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor
Young, Robert J.,Alderton, Wendy,Angell, Anthony D.R.,Beswick, Paul J.,Brown, David,Chambers, C. Lynn,Crowe, Miriam C.,Dawson, John,Hamlett, Christopher C.F.,Hodgson, Simon T.,Kleanthous, Savvas,Knowles, Richard G.,Russell, Linda J.,Stocker, Richard,Woolven, James M.
, p. 3037 - 3040 (2011/06/26)
Heteroalicyclic carboxamidines were synthesised and evaluated as inhibitors of nitric oxide synthases. (2R)-2-Pyrrolidinecarboxamidine, in particular, was shown to be a highly potent in vitro (IC50 = 0.12 μM) and selective iNOS inhibitor (>100-fold vs both eNOS and nNOS), with probable binding to the key anchoring glutamate residue and co-ordination to the haem iron.
Improved pinner reaction with CPME as a solvent
Watanabe, Kiyoshi,Kogoshi, Naoto,Miki, Hideaki,Torisawa, Yasuhiro
scheme or table, p. 2008 - 2013 (2009/10/24)
The classical Pinner reaction has been improved by the utilization of 4N-HCl solution in cyclopentyl methyl ether (CPME) as a solvent, wherein direct isolation of the product was possible by a simple filtration.
