3217-94-5

Usage

Uses

Used in Pharmaceutical Synthesis:
Cyclopentane carboxamide is utilized as a building block in the synthesis of various pharmaceuticals. Its chemical structure allows it to be a key component in the creation of different medicinal compounds, contributing to the development of new drugs and therapies.
Used in Pesticide Production:
In the agricultural sector, cyclopentane carboxamide serves as a building block for the synthesis of pesticides. Its incorporation into these products helps in the development of effective pest control agents, ensuring crop protection and increased agricultural yields.
Used as a Solvent:
Cyclopentane carboxamide is employed as a solvent in various chemical processes. Its properties make it suitable for dissolving a range of substances, facilitating reactions and improving the efficiency of industrial processes.
Used as a Plasticizer:
In the plastics industry, cyclopentane carboxamide is used as a plasticizer. It helps to increase the flexibility and workability of plastic materials, making them more suitable for a variety of applications.
It is crucial to adhere to proper safety procedures and guidelines when working with cyclopentane carboxamide to ensure the well-being of workers and the environment.

InChI:InChI=1/C6H11NO/c7-6(8)5-3-1-2-4-5/h5H,1-4H2,(H2,7,8)

Upstream product

• 109152-86-5 cyclopentanecarboximidic acid methyl ester hydrochloride 
• 201230-82-2 carbon monoxide 
• 142-29-0 cyclopentene 
• 4254-02-8 cyclopentanecarbonitrile 
• 107-21-1 ethylene glycol 
• 68-12-2 N,N-dimethyl-formamide 
• 22809-37-6 6-bromohexanoyl chloride 
• 611-10-9 2-ethoxycarbonyl-1-cyclopentanone 
• 73825-69-1 acetic acid-(1-cyano-cyclopentyl ester) 
• 5117-85-1 1-hydroxycyclopentanecarbonitrile 
• 3047-38-9 cyclopent-1-enecarbonitrile 
• 3400-47-3 1,2-diaza-spiro[2.5]oct-1-en-4-one 
• 5453-85-0 ethyl cyclopentanecarboxylate 
• 3400-45-1 cyclopentanecarboxylic acid 

Downstream Products

• 6053-81-2 cyclopentylmethylamine 
• 3400-41-7 N-phenylcyclopentanecarboxamide 
• 13691-84-4 N-(3-(trifluoromethyl)phenyl)cyclopentanecarboxamide 
• 109152-86-5 cyclopentanecarboximidic acid methyl ester hydrochloride 
• 42202-73-3 cyclopentanecarbothioamide 
• 4254-02-8 cyclopentanecarbonitrile 

Relevant academic research and scientific papers

Corresponding amine nitrile and method of manufacturing thereof

The invention relates to a manufacturing method of nitrile. Compared with the prior art, the manufacturing method has the characteristics of significantly reduced using amount of an ammonia source, low environmental pressure, low energy consumption, low production cost, high purity and yield of a nitrile product and the like, and nitrile with a more complex structure can be obtained. The invention also relates to a method for manufacturing corresponding amine from nitrile.

SUBSTITUTED NICOTINIMIDE INHIBITORS OF BTK AND THEIR PREPARATION AND USE IN THE TREATMENT OF CANCER, INFLAMMATION AND AUTOIMMUNE DISEASE

Compounds of Formula I, as shown below and defined herein: and pharmaceutically acceptable salts, syntheses, intermediates, formulations, and methods of treating diseases including cancer, inflammation, and autoimmune disease mediated at least in part by Bruton's Tyrosine Kinase (BTK).

HETEROCYCLE-SUBSTITUED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES

The present invention relates to novel Heterocycle-Substituted Tetracyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, A', R 2 R 3, R 4 and R are as defined herein. The present i

THIAZOLYL-SUBSTITUED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES

The present invention relates to novel Thiazolyl-Substituted Tetracyclic Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, A', R2R3, R4 and R5 are as defined herein. The present

N-Acyl-N'-(pyridin-2-yl) Ureas and Analogs Exhibiting Anti-Cancer and Anti-Proliferative Activities

Described are compounds of Formula I which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-FMS, c-KIT, or PDGFR kinases.

Hypervalent iodine catalyzed hofmann rearrangement of carboxamides using oxone as terminal oxidant

Hofmann rearrangement of carboxamides to carbamates using Oxone as an oxidant can be efficiently catalyzed by iodobenzene. This reaction involves hypervalent iodine species generated in situ from catalytic amount of PhI and Oxone in the presence of 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) in aqueous methanol solutions. Under these conditions, Hofmann rearrangement of various carboxamides affords corresponding carbamates in high yields.

Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; The identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor

Heteroalicyclic carboxamidines were synthesised and evaluated as inhibitors of nitric oxide synthases. (2R)-2-Pyrrolidinecarboxamidine, in particular, was shown to be a highly potent in vitro (IC50 = 0.12 μM) and selective iNOS inhibitor (>100-fold vs both eNOS and nNOS), with probable binding to the key anchoring glutamate residue and co-ordination to the haem iron.

Gold Activation of Nitriles: Catalytic Hydration to Amides

A gold-based catalytic system that efficiently mediates the hydration of a broad spectrum of nitriles, including aromatic, heteroaromatic and aliphatic examples and efficiently catalyze the hydration of a range of organonitriles has been reported. Nitriles are considered inert in the context gold catalysis and have only been used as reaction solvent or as throw-away ligands in well-defined cationic gold catalysis. The obtained product was purified by flash chromatography using a gradient of pentane/ethyl acetate and compound 1 was isolated as a colorless solid. Aromatic substrates bearing two nitrile groups as in rn-benzenedinitrile and p-benzenedinitrile underwent double nitrile hydration and afforded excellent yields in the corresponding diamides. There is high relevance for the use of cationic gold complexes bearing such ligands and should have important implications in catalysis.

THIAZOLES, IMIDAZOLES, AND PYRAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES

The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and the compositions in the treatment of

Mild oxidative one-carbon homologation of aldehyde to amide

One-carbon homologation of aldehyde into amide is realized in one-pot by its reaction with potassium α-p-methoxyphenyl-α-isocyano acetic acid (1c) and hydrochloride salt of dimethylamine (3a) in toluene at room temperature followed by acidic workup. In this multicomponent reaction, 1c served as donor of the CONH2 function to aldehyde, while the dimethylamine acted as a shuttle molecule to initiate/terminate the sequence and to mediate the internal redox process of one of the three-component adducts. Ready accessibility, nominal cost of the reagents, and mild conditions are attractive features of the present method. Copyright