1091621-61-2

Basic information

• Product Name: Loxoprofen Ring-opening IMpurity
• Synonyms: Loxoprofen Ring-opening IMpurity;Loxoprofen Impurity K;Loxoprofen Impurity 12;Loxoprofen Impurity 3
• CAS NO: 1091621-61-2
• Molecular Formula: C15H18O5
• Molecular Weight: 278.3
• Mol File: 1091621-61-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 504.8±35.0 °C(Predicted)
• Appearance: /
• Density: 1.238±0.06 g/cm3(Predicted)
• PKA: 4.32±0.10(Predicted)
• CAS DataBase Reference: Loxoprofen Ring-opening IMpurity(CAS DataBase Reference)
• NIST Chemistry Reference: Loxoprofen Ring-opening IMpurity(1091621-61-2)
• EPA Substance Registry System: Loxoprofen Ring-opening IMpurity(1091621-61-2)

Safety Data

• Hazardous Substances Data: 1091621-61-2(Hazardous Substances Data)

Usage

Uses

4-(1-Carboxyethyl)-δ-oxo-benzenehexanoic Acid is a degradation product of Loxoprofen (L472900, Na salt), a non-selective nonsteroidal anti-inflammatory drug (NSAID) that has been effective in reducing atherosclerosis in mice by reducing inflammation. It becomes active after metabolism in the body and inhibits the activation of cyclooxygenase.

Upstream product

• 111128-12-2 2-[4-(bromomethyl)phenyl]propanoic acid 
• 80530-55-8 2-[(p-chloromethyl)phenyl]propionic acid 

Relevant articles and documents

Preparation method of loxoprofen sodium ring opened impurity

The invention relates to a preparation method of a loxoprofen sodium ring opened impurity, and belongs to the technical field of bulk drug preparation. The preparation method comprises the following steps: step one, carrying out substitution reactions between a compound represented by a formula I and hexamethylene tetramine in an organic solvent A, hydrolyzing the reaction product by inorganic acids to obtain a compound represented by a formula II; carrying out condensation reactions between the compound represented by the formula II and a compound represented by a formula III in an organic solvent B to obtain a compound represented by a formula IV; carrying out oxidation and ring opening reactions of the compound represented by the formula IV under the effect of an oxidant and inorganic alkalis to obtain the loxoprofen sodium ring opened impurity represented by a formula V. The invention provides a preparation method of the loxoprofen sodium ring opened impurity.