109193-24-0Relevant articles and documents
Cardioprotective effect of novel sulphonamides-1,3,5-triazine conjugates against ischaemic–reperfusion injury via selective inhibition of MMP-9
Zheng, Xiao-Zhu,Zhou, Jia-Li,Ye, Jing,Guo, Pei-Pei,Lin, Chun-Shui
, p. 756 - 765 (2016/10/19)
Diseases affecting cardiovascular system are ranked as a top most cause of morbidity and mortality. Herein, a novel class sulphonamides-1,3,5-triazine conjugates have been synthesized and tested for inhibitory activity against MMP-2 and MMP-9. The results of the study showed that these molecules efficiently inhibit MMP-9 than MMP-2, revealing compound 8e as the most potent inhibitor (IC50?=?2.34?±?0.56?nm). Due to involvement of MMP-9 in many cardiovascular diseases, particularly in myocardial ischaemia (MI), compound 8e was further subjected for the determination of the protective effect on isoproterenol (ISO)-induced myocardial injury in rats.
Synthesis and antimicrobial activity of some new cyanopyridines, isoxazoles, pyrazoles, and pyrimidines bearing sulfonamide moiety
Moustafa, Osama S.,Ahmad, Ragaa A.
, p. 475 - 484 (2007/10/03)
Reaction of p-aminoacetophenone 1 with p-substituted benzenesulfonyl chloride 2a,b in pyridine afforded p-acetyl derivatives 3a,b, which was then condensed with araldehydes to yield the corresponding chalcones 4a-f. On condensation of latter chalcones wit
