109205-68-7

Usage

Uses

Used in Nutritional Supplements:
5-(Hydroxymethyl) pyridin-2(1H)-one is used as a nutritional supplement to support various bodily functions, including metabolism, immune system function, and nervous system health. It helps in the production of neurotransmitters like serotonin and dopamine, which are essential for mood regulation and cognitive function.
Used in Food and Beverage Industry:
In the food and beverage industry, 5-(hydroxymethyl) pyridin-2(1H)-one is used as a fortifying agent to enhance the nutritional value of products, ensuring consumers receive adequate amounts of this essential vitamin.
Used in Pharmaceutical Applications:
5-(Hydroxymethyl) pyridin-2(1H)-one is used in the pharmaceutical industry for the development of medications that address vitamin B6 deficiency and its associated symptoms, such as anemia, depression, and weakened immune function.
Used in Cosmetics and Personal Care Products:
In the cosmetics and personal care industry, 5-(hydroxymethyl) pyridin-2(1H)-one is used as an ingredient in skincare and hair care products to promote healthy skin and hair, thanks to its role in maintaining overall health and well-being.
Used in Animal Nutrition:
5-(Hydroxymethyl) pyridin-2(1H)-one is also used in animal nutrition to ensure that livestock and pets receive adequate amounts of vitamin B6, contributing to their overall health and well-being.

InChI:InChI=1/C6H7NO2/c8-4-5-1-2-6(9)7-3-5/h1-3,8H,4H2,(H,7,9)

Upstream product

• 66171-50-4 methyl 6-hydroxynicotinate 
• 106984-91-2 6-oxo-1,6-dihydropyridine-3-carbaldehyde 
• 66171-50-4 6-oxo-1,6-dihydropyridin-3-carboxylic acid methyl ester 
• 5006-66-6 6-hydroxy-3-pyridinecarboxylic acid 
• 18617-50-0 ethyl 6-hydroxypyridine-3-carboxylate 

Downstream Products

• 70258-18-3 2-chloro-5-(chloromethyl)pyridine 
• 1375098-07-9 (6-(difluoromethoxy)pyridin-3-yl)methanol 
• 366448-37-5 5-bromomethyl-2-pyridone 

Relevant academic research and scientific papers

Tri- and difluoromethoxylated N-based heterocycles ? Synthesis and insecticidal activity of novel F3CO- and F2HCO-analogues of Imidacloprid and Thiacloprid

The preparation of F3CO- and F2HCO-analogues of Imidacloprid and Thiacloprid and the evaluation of their biological activity have been performed. For this purpose, a first synthetic approach allowed the preparation of a desired F3CO-containing key intermediate. To allow a facile access to the second F2HCO-containing key intermediate, the difluoromethylation of hydroxylated N-based heterocycles has been developed using difluoromethyl triflate (a liquid non-ODS reagent) under air in aqueous conditions and with very short reaction time. The broad diversity of compatible heterocycles includes a large series of substituted hydroxy-pyridines, but also ?pyrazoles, ?pyrazine, ?pyridazine, and ?quinolines. The couplings of both key intermediates with the required 4,5-dihydro-N-nitro-1H-imidazol-2-amine and [N(Z)]-N-2-thiazolidinylidene-cyanamide were successfully achieved using literature conditions. This work enables the preparation of valuable building blocks, which could lead to the discovery of new bioactive entities.

BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF GLYTL MEDIATED DISORDERS

The present invention relates to benzoxazinone derivatives, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in treating disorders mediated by GlyT1, including neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder.

Novel pyridones and their use as modulators of serine hydrolase enzymes

This invention relates to a compound of formula I: or a pharmaceutically acceptable salt thereof; in which preferably R3, R4 and R6 are each hydrogen; X is C═O or CH2; and R7 and R8 are each independently selected from the group consisting of hydrogen, (C1-C12)alkyl, (C3-C8)cycloalkyl and (C1-C2)alkyl(C6-C14)aryl; or R7 and R8 when taken together form a (C2-C7)alkylene group; or —NR7R8 together forms a (C2-C14)heterocyclic or substituted (C2-C14)heterocyclic. Such compounds modulate the activity of serine hydrolases and can be used in pharmaceutical compositions for the treatment of Alzheimer's disease.

Process for the production of 2-chloro-5-chloromethyl-pyridine

A process for the production of 2-chloro-5-chloromethylpyridine of the formula: starting from 6-hydroxynicotinic acid of the formula: In this way 6-hydroxynicotinic acid is reacted with an acid chloride to 6-hydroxynicotinoyl chloride of the formula: The latter is then catalytically hydrogenated with hydrogen to 6-hydroxy-5-hydroxymethylpyridine of the formula: The latter is then catalytically hydrogenated with hydrogen to 2-hydroxy-5-hydroxymethylpyridine of the formula: which is then chlorinated to the end product according to formula I.

Preparation of 2-chloro-5-chloromethylpyridine

A process for the preparation of 2-chloro-5-chloromethyl-pyridine of the formula STR1 which comprises reacting nicotinic acid of the formula STR2 with phosphorus pentachloride to produce 3-trichloromethylpyridine of the formula STR3 reacting the 3-trichloromethylpyridine in a 2nd step with an alkali metal alkoxide of the formula in which R represents alkyl and M represaents an alkali metal cation, to produce a pyridine ether acetal of the formula STR4 reacting the pyridine ether acetal in a 3rd step with dilute aqueous acid to produce pyridone aldehyde of the formula STR5 hydrogenating the pyridone aldehyde in a 4th step with molecular hydrogen in the presence of a hydrogenation catalyst to produce the pyridylmethanol compound of the formula STR6 and reducing the pyridylmethanol compound in a 5th step with a chlorinating agent.