106984-91-2

Basic information

• Product Name: 2-HYDROXY-5-FORMYLPYRIDINE
• Synonyms: 2-HYDROXY-5-FORMYLPYRIDINE;2-HYDROXYPYRIDINE-5-CARBOXALDEHYDE;6-HYDROXYNICOTINALDEHYDE;6-OXO-1,6-DIHYDRO-PYRIDINE-3-CARBALDEHYDE;3-Pyridinecarboxaldehyde, 1,6-dihydro-6-oxo- (9CI);6-HYDROXYNICOTINALDEHYDE (6-HYDROXY-3-PYRIDINE CARBOXYALDEHYDE);6-Hydroxypyridine-3-carbaldehyde;6-Hydroxynicotinaldehyde 95%+
• CAS NO: 106984-91-2
• Molecular Formula: C₆H₅NO₂
• Molecular Weight: 123.11
• Product Categories: ALDEHYDE;PYRIDINE;Pyridines, Pyrimidines, Purines and Pteredines;Pyridines
• Mol File: 106984-91-2.mol
• Article Data: 14

Chemical Properties

• Melting Point: 216-220°C
• Boiling Point: 333.73 °C at 760 mmHg
• Flash Point: 175.085 °C
• Appearance: /
• Density: 1.366 g/cm³
• Vapor Pressure: 0.000134mmHg at 25°C
• Refractive Index: 1.636
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 10.18±0.10(Predicted)
• CAS DataBase Reference: 2-HYDROXY-5-FORMYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-5-FORMYLPYRIDINE(106984-91-2)
• EPA Substance Registry System: 2-HYDROXY-5-FORMYLPYRIDINE(106984-91-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-43-36-22
• Safety Statements: 26-36/37/39-36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 106984-91-2(Hazardous Substances Data)

Usage

Description

2-HYDROXY-5-FORMYLPYRIDINE, also known as 5-formyl-2-hydroxypyridine, is a chemical compound with the molecular formula C6H5NO2. It is a derivative of pyridine and is characterized by a hydroxyl group and a formyl group at the 2 and 5 positions, respectively. 2-HYDROXY-5-FORMYLPYRIDINE is recognized for its potential in various chemical applications due to its unique structure.

Uses

Used in Pharmaceutical Synthesis:
2-HYDROXY-5-FORMYLPYRIDINE is used as a building block for the synthesis of pharmaceuticals, contributing to the development of new drugs. Its presence in the molecular structure can influence the properties and effectiveness of the final product.
Used in Agrochemical Production:
In the agrochemical industry, 2-HYDROXY-5-FORMYLPYRIDINE is used as a key component in the creation of various agrochemicals. Its role is crucial in formulating products that can enhance crop protection and yield.
Used in Dye Manufacturing:
2-HYDROXY-5-FORMYLPYRIDINE is utilized in the production of dyes, where its chemical properties contribute to the color and stability of the dyes produced.
Used in Organic Chemistry Research:
Due to its unique structure, 2-HYDROXY-5-FORMYLPYRIDINE is used in the field of organic chemistry for research purposes. It serves as a valuable compound for exploring new chemical reactions and discovering novel materials.
Used in Material Science:
2-HYDROXY-5-FORMYLPYRIDINE is employed in material science for the development of new materials with specific properties. Its versatility in chemical reactions allows for the creation of materials with tailored characteristics for various applications.

InChI:InChI=1/C6H5NO2/c8-4-5-1-2-6(9)7-3-5/h1-4H,(H,7,9)

Upstream product

• 624-28-2 2,5-dibromopyridine 
• 83664-33-9 2-(benzyloxy)-5-bromopyridine 
• 635712-99-1 6-benzyloxypyridine-3-carboxaldehyde 
• 65873-72-5 6-methoxy-3-pyridinecarboxaldehyde 
• 114951-35-8 3-pyridinecarbaldehyde diacetate 1-oxide 
• 114951-44-9 3-pyridine carbaldehyde diacetate 
• 884495-36-7 6-chloro-2-methylpyridine-3-carbaldehyde 
• 95652-83-8 5-(dimethoxymethyl)-2-methoxypyridine 
• 13472-85-0 2-methoxy-5-bromopyridine 
• 18327-02-1 2-oxo-2H-pyran-5-carbaldehyde 

Downstream Products

• 109205-68-7 5-(hydroxymethyl)-1,2-dihydropyridin-2-one 
• 914918-78-8 6-oxo-1-phenyl-1,6-dihydropyridine-3-carbaldehyde 
• 1571034-47-3 1-(3-bromobenzyl)-5-(1-hydroxy-3-(((4-methoxybenzyl)oxy)imino)-3-(4-(trifluoromethoxy)phenyl)propyl)pyridin-2(1H)-one 
• 1571034-54-2 1-(3-bromobenzyl)-5-(3-(((4-methoxybenzyl)oxy)imino)-3-(4-(trifluoromethoxy)phenyl)propanoyl)pyridin-2(1H)-one 
• 1571034-57-5 1-(3-bromobenzyl)-5-(3-(4-(trifluoromethoxy)phenyl)isoxazol-5-yl)pyridin-2(1H)-one 
• 1571034-39-3 1-(3-(4-(methylsulfonyl)piperidin-1-yl)benzyl)-5-(3-(4-(trifluoromethoxy)phenyl)isoxazol-5-yl)pyridin-2(1H)-one 
• 1211577-99-9 6-(difluoromethoxy)nicotinaldehyde 

Relevant articles and documents

Pyridone derivatives carrying radical moieties: Hydrogen-bonded structures, magnetic properties, and metal coordination

Pyridone derivatives carrying radical moieties were prepared, namely a nitronyl nitroxide derivative 5-(4′,4′,5′,5′- tetramethylimidazoline-3′-oxide-1′-oxyl)-2(1H)-pyridone (1) and a verdazyl derivative 1,5-dimethyl-3-[2(1H)-pyridone]-6-oxoverdazyl (2). In the solid state, 1 and 2 form, via N-H?O intermolecular hydrogen bonds between the pyridone moieties, a zigzag one-dimensional chain structure and a cyclic dimer structure, respectively. These compounds exhibit antiferromagnetic intermolecular interactions. Mononuclear metal complexes [M(hfac) 2(1)2] (M = CuII, MnII; hfac = bis(hexafluoroacetylacetonate)) were prepared in which trans-[M(hfac) 2] are coordinated with the carbonyl oxygen of the pyridone ligands. Cyclic hydrogen bonds between the mononuclear units result in the formation of one-dimensional chains. Small antiferromagnetic (for CuII) and ferromagnetic (for MnII) exchange interactions between the metal ion and the ligands were observed.

AGONISTS OF GPR40

The present invention relates to compounds that have the ability to modulate the activity of GPR40 and are there-fore useful in the treatment of GPR40 related disorders. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders related to GPR40 activity.

COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY AND FIBROTIC DISORDERS

Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.