66171-50-4Relevant articles and documents
A Diels-Alder Route to Pyridone and Piperidone Derivatives
Sainte, Francy,Serckx-Poncin, Beatrice,Hesbain-Frisque, Anne-Marie,Ghosez, Leon
, p. 1428 - 1430 (1982)
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A new method using 1,3,5-triazine as an umpolung hydrogen cyanide equivalent toward the syntheses of isoquinolinone and 2-pyridone derivatives
Hayashida, Joji,Yoshida, Shinya
supporting information, p. 3876 - 3879 (2018/10/02)
An investigation of Hermecz and Hartenstein's cyclization methods was conducted. Overcoming the limited substrate scope allowed the expansion of the synthetic application of 1,3,5-triazine as an umpolung hydrogen cyanide equivalent. The reaction proceeded under mild conditions to provide various isoquinolinone and 2-pyridone derivatives with excellent yields.
Preparation method of 2-chloro-5-cyano nitrogen-containing six-membered heterocyclic compound
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Paragraph 0069; 0070; 0071; 0072, (2019/01/08)
The invention provides a preparation method of a 2-chloro-5-cyano nitrogen-containing six-membered heterocyclic compound. The method comprises the following steps: using a 2-hydroxy-5-bromine nitrogen-containing six-membered heterocyclic compound as a raw material, under existence of a catalyst, in atmosphere of carbon monoxide gas, using methanol as a solvent, and performing a coupling reaction to obtain a methyl 2-hydroxyl nitrogen-containing six-membered heterocyclic ring-5-carboxylate, and sequentially performing an aminolysis reaction, a chlorination reaction with phosphorus oxychloride,and an oxidation reaction to obtain the 2-chloro-5-cyano nitrogen-containing six-membered heterocyclic compound. The preparation method has the advantages of short route and easily available raw material, a post-processing method is simple, no column chromatography is required after each reaction, the reaction product can be purified only by washing and extraction of a solvent, amplification is realized, industrial production is carried out, the method accords with environmental protection requirements, and has important value for actual production.
