1092120-18-7

Basic information

• Product Name: C₂₈H₃₈FN₃O₃
• CAS NO: 1092120-18-7
• Molecular Weight: 483.626
• Mol File: 1092120-18-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₈H₃₈FN₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₃₈FN₃O₃(1092120-18-7)
• EPA Substance Registry System: C₂₈H₃₈FN₃O₃(1092120-18-7)

Safety Data

• Hazardous Substances Data: 1092120-18-7(Hazardous Substances Data)

Upstream product

• 163271-06-5 4-amino-1-benzyl-4-methylpiperidine 
• 218608-98-1 (3R)-3-[(tert-butoxycarbonyl)amino]-4-(2-fluorophenyl)butanoic acid 

Downstream Products

• 1092119-86-2 C₂₃H₃₀FN₃O 

Relevant articles and documents

(3R)-3-Amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamide as a potent dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides and 3-amino-N-(4-aryltetrahydropyran-4-yl)butanamides were synthesized and evaluated as dipeptidyl peptidase IV (DPP-IV) inhibitors. Derivatives incorporating the 6-substituted benzothiazole group showed highly potent DPP-IV inhibitory activity. Oral administration of (3R)-3-amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamide (12u) reduced blood glucose excursion in an oral glucose tolerance test.