109240-65-5Relevant academic research and scientific papers
ASYMMETRIC SYNTHESIS OF (R)-(+)- AND (S)-(-)-2,2,4-TRIMETHYL-4-(HYDROXYMETHYL)-1,3-DIOXOLANE OF HIGH ENANTIOMERIC PURITY
Tanner, David,Somfai, Peter
, p. 5985 - 5990 (1986)
The title compounds, 1 and 1', are readily available in four steps from 2-benzyloxymethyl-2-propen-1-ol, the key step being Sharpless asymmetric epoxidation to give the chiral epoxides 5 or 5'.The total chemical yield of 1 or 1' is 50percent, the final pr
Enantioselective syntheses of the proposed structures of cytotoxic macrolides iriomoteolide-1a and -1b
Ghosh, Arun K.,Yuan, Hao
supporting information; experimental part, p. 3120 - 3123 (2010/09/16)
(Figure Presented) Enantioselective total syntheses of the proposed structures of macrolide cytotoxic agents iriomoteolide-1a and -1b have been accomplished. The synthesis was carried out in a convergent and stereoselective manner. However, the present wo
Chiral primary amine catalyzed asymmetric epoxidation of α-substituted acroleins
Li, Jiuyuan,Fu, Niankai,Zhang, Long,Zhou, Pengxin,Luo, Sanzhong,Cheng, Jin-Pei
experimental part, p. 6840 - 6849 (2011/03/19)
1,1-Disubstituted terminal alkenes remain challenging substrates in asymmetric epoxidation reactions. In this study, chiral primary amines are shown to catalyze the asymmetric epoxidation of α-substituted acroleins, a versatile type of 1,1-disubstituted t
Synthesis and evaluation of a new class of tertiary alcohol based BACE-1 inhibitors
Russo, Francesco,W?ngsell, Fredrik,S?vmarker, Jonas,Jacobsson, Micael,Larhed, Mats
experimental part, p. 10047 - 10059 (2010/02/28)
BACE-1 has emerged as one of the best characterized targets for future Alzheimer therapy. In accordance with the successful identification of masked inhibitors of HIV-1 protease, we envisioned that tert-alcohol containing transition-state mimicking struct
