ASYMMETRIC SYNTHESIS OF (R)-(+)- AND (S)-(-)-2,2,4-TRIMETHYL-4-(HYDROXYMETHYL)-1,3-DIOXOLANE OF HIGH ENANTIOMERIC PURITY

Article abstract of DOI:10.1016/S0040-4020(01)96082-X

The title compounds, 1 and 1', are readily available in four steps from 2-benzyloxymethyl-2-propen-1-ol, the key step being Sharpless asymmetric epoxidation to give the chiral epoxides 5 or 5'.The total chemical yield of 1 or 1' is 50percent, the final pr