1092554-87-4 Usage
Description
Bis-Propargyl-PEG9 is a crosslinking reagent that contains two propargyl groups. These functional groups allow the formation of triazole linkages with azide-bearing compounds in the presence of a copper catalyst. The molecule's hydrophilicity is enhanced due to the presence of a PEG (polyethylene glycol) chain, which contributes to its solubility and stability in aqueous environments.
Uses
Used in Pharmaceutical Industry:
Bis-Propargyl-PEG9 is used as a bivalent estrogen receptor ligand for the development of targeted drug delivery systems. Its ability to form stable triazole linkages with azide-bearing compounds makes it a valuable tool in the creation of bioconjugates and drug carriers with enhanced specificity and efficacy.
Used in Bioconjugation and Drug Development:
In the field of bioconjugation and drug development, Bis-Propargyl-PEG9 serves as a versatile crosslinking agent. Its propargyl groups facilitate the formation of stable covalent bonds with azide-containing biomolecules, such as proteins, peptides, and nucleic acids. This property is particularly useful in the development of novel bioconjugates, drug carriers, and imaging agents with improved targeting and delivery capabilities.
Used in Material Science:
Bis-Propargyl-PEG9 can also be utilized in material science for the synthesis of functional polymers and hydrogels. The incorporation of the PEG chain and the ability to form triazole linkages can lead to the development of materials with tailored properties, such as enhanced biocompatibility, tunable mechanical properties, and controlled drug release profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 1092554-87-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,9,2,5,5 and 4 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1092554-87:
(9*1)+(8*0)+(7*9)+(6*2)+(5*5)+(4*5)+(3*4)+(2*8)+(1*7)=164
164 % 10 = 4
So 1092554-87-4 is a valid CAS Registry Number.
1092554-87-4Relevant articles and documents
Semisynthetic Lipopeptides Derived from Nisin Display Antibacterial Activity and Lipid II Binding on Par with That of the Parent Compound
Koopmans, Timo,Wood, Thomas M.,'T Hart, Peter,Kleijn, Laurens H. J.,Hendrickx, Antoni P. A.,Willems, Rob J. L.,Breukink, Eefjan,Martin, Nathaniel I.
, p. 9382 - 9389 (2015)
The lipid II-binding N-terminus of nisin, comprising the so-called A/B ring system, was synthetically modified to provide antibacterially active and proteolytically stable derivatives. A variety of lipids were coupled to the C-terminus of the nisin A/B ri
Convergent synthesis and characterization of dumbbell type dendritic materials by click chemistry
Sung, Sae Reum,Han, Seung Choul,Jin, Sung-Ho,Lee, Jae Wook
, p. 3933 - 3940 (2012/03/26)
General, fast, and efficient stitching methods for the synthesis of dendrimers with linear PEG units at a core, as dendritic-linear-dendritic materials, were developed. The synthetic strategy involved the click reaction between an alkyne and an azide. The
