1092563-68-2

Basic information

• Product Name: 1-(1-Boc-4-piperidyl)-3-methylpyrazole-4-boronic Acid Pinacol Ester
• Synonyms: 1-(1-Boc-4-piperidyl)-3-methylpyrazole-4-boronic Acid Pinacol Ester;tert-Butyl 4-(3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate;tert-Butyl 4-(3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperid
• CAS NO: 1092563-68-2
• Molecular Formula: C20H34BN3O4
• Molecular Weight: 391.32
• Mol File: 1092563-68-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 1-(1-Boc-4-piperidyl)-3-methylpyrazole-4-boronic Acid Pinacol Ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-Boc-4-piperidyl)-3-methylpyrazole-4-boronic Acid Pinacol Ester(1092563-68-2)
• EPA Substance Registry System: 1-(1-Boc-4-piperidyl)-3-methylpyrazole-4-boronic Acid Pinacol Ester(1092563-68-2)

Safety Data

• Hazardous Substances Data: 1092563-68-2(Hazardous Substances Data)

Usage

General Description

1-(1-Boc-4-piperidyl)-3-methylpyrazole-4-boronic Acid Pinacol Ester is a boronic acid derivative that is commonly used in organic synthesis and medicinal chemistry. It contains a Boc-protected piperidine group and a pyrazole-4-boronic acid pinacol ester. The Boc group provides steric hindrance to the piperidine nitrogen, making it less reactive and more stable. The boronic acid group is a versatile functional group that can undergo various reactions, including Suzuki-Miyaura cross-coupling reactions, making it valuable for the construction of complex organic molecules. 1-(1-Boc-4-piperidyl)-3-methylpyrazole-4-boronic Acid Pinacol Ester is used as a building block in the synthesis of pharmaceuticals and other biologically active compounds due to its ability to form carbon-carbon bonds and its potential for binding to biological targets.

Upstream product

• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 13808-64-5 4-bromo-3-methyl-1H-pyrazole 
• 73183-34-3 bis(pinacol)diborane 
• 141699-59-4 1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate 
• 1076223-99-8 tert-butyl 4-(4-bromo-5-methyl-1H-pyrazol-1-yl)piperidine-1-carboxylate 
• 1092500-89-4 tert-butyl 4-(4-bromo-3-methyl-1H-pyrazol-1-yl)piperidine-1-carboxylate 

Relevant articles and documents

AZAINDOLE DERIVATIVE AND USE THEREOF AS FGFR AND C-MET INHIBITOR

A series of pyrazolopymidine derivatives, and use thereof in the preparation of a medicament for treating disease associated with FGFR and c-Met. The pyrazolopymidine derivative is a compound represented by formula (I), a tautomer, or a pharmaceutically acceptable salt thereof.

2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS

The invention concerns pyrazine derivatives of Formula (I) or a pharmaceutically-acceptable salt thereof, wherein each of G1, G2, Ring A, R1, m, R2, R3, n and R4 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositionscontaining them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders.

QUINOXALINE DERIVATIVES AS INHIBITORS OF THE TYROSINE KINASE ACTIVITY OF JANUS KINASES

The present invention relates to quinoxaline compound of the formula (I): wherein R1 is carbocyclyl or heterocyclyl, either of which is optionally substituted with 1, 2, 3, 4 or 5 R7; R2 is carbocyclyl or heterocyclyl, either of which is optionally substituted with 1, 2, 3, 4 or 5 R8; R3, R4, R5 and R6 are each independently hydrogen or R9; and R7, R8 and R9 are each independently selected from organic and inorganic substituents, their use in therapy of diseases, in particular diseases mediated by the tyrosine kinase activity of Janus kinases, including JAK-2 and JAK-3 kinases