1092571-57-7Relevant articles and documents
A practical method for enantioselective synthesis of all-carbon quaternary stereogenic centers through NHC-Cu-catalyzed conjugate additions of alkyl- and arylzinc reagents to β-substituted cyclic enones
Lee, Kang-Sang,Brown, M. Kevin,Hird, Alexander W.,Hoveyda, Amir H.
, p. 7182 - 7184 (2006)
We present the first examples of Cu-catalyzed enantioselective conjugate additions of alkyl- and arylzinc reagents to unactivated cyclic β-substituted enones. Transformations are promoted in the presence of 2.5-15 mol % of a readily available chiral NHC-b
Synthesis of diverse β-quaternary ketones via palladium-catalyzed asymmetric conjugate addition of arylboronic acids to cyclic enones
Holder, Jeffrey C.,Goodman, Emmett D.,Kikushima, Kotaro,Gatti, Michele,Marziale, Alexander N.,Stoltz, Brian M.
, p. 5781 - 5792 (2015/08/03)
Abstract The development and optimization of a palladium-catalyzed asymmetric conjugate addition of arylboronic acids to cyclic enone conjugate acceptors is described. These reactions employ air-stable and readily-available reagents in an operationally si
Rhodium-catalyzed asymmetric 1,4-addition of aryl alanes to trisubstituted enones: Binap as an effective ligand in the formation of quaternary stereocenters
Hawner, Christine,Mueller, Daniel,Gremaud, Ludovic,Felouat, Abdellah,Woodward, Simon,Alexakis, Alexandre
supporting information; experimental part, p. 7769 - 7772 (2010/12/25)
All for one and 1,4-all: Readily available aryl alanes are used in the rhodium-catalyzed asymmetric conjugate addition reaction with a variety of cyclic and acyclic enones. The enhanced reactivity of the system allows the use of the common binap ligand for the generation of quaternary benzylic stereocenters in excellent enantioselectivity (see scheme).
