1092804-15-3Relevant academic research and scientific papers
Carbocyclic bicyclic nucleic acid analogs
-
, (2012/10/08)
Provided herein are saturated and unsaturated carbocyclic bicyclic nucleosides, oligomeric compounds prepared therefrom and methods of using these oligomeric compounds. The saturated and unsaturated carbocyclic bicyclic nucleosides are useful for enhancin
6-Disubstituted Or Unsaturated Bicyclic Nucleic Acid Analogs
-
Page/Page column 17-18, (2011/04/14)
The present disclosure describes 6-disubstituted bicyclic nucleosides, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, the 6-disubstituted bicyclic nucleosides each comprise a 2′-O—C(Ri)(R2)-4′ or
6-MODIFIED BICYCLIC NUCLEIC ACID ANALOGS
-
Page/Page column 34-35, (2010/11/28)
The present invention provides 6-modified bicyclic nucleoside analogs and oligomeric compounds comprising these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 6-position. These bicyclicnucleoside analogs are useful for enhancing properties of oligomeric compounds including nuclease resistance.
