109296-31-3

Upstream product

• 106367-31-1 Benzyl-[3-chloro-2,2-dimethyl-1-phenyl-prop-(E)-ylidene]-amine 
• 99315-24-9 Benzyl-[3-chloro-2,2-dimethyl-1-phenyl-prop-(E)-ylidene]-amine 
• 4301-07-9 β-Chlor-pivalophenon 
• 56010-63-0 2,2-dimethyl-3-hydroxy-1-phenylpropan-1-one 
• 611-70-1 phenyl isopropyl ketone 

Downstream Products

• 109296-40-4 2,2-dimethyl-1-phenylcyclopropylamine 
• 128419-49-8 N-(2,2-dimethyl-1-phenyl-1-cyclopropyl)trifluoroacetamide 
• 123445-53-4 (+/-)-2,2-dimethyl-1-aminocyclopropane-1-carboxylic acid 

Relevant academic research and scientific papers

Synthesis of 2,2-dialkylcyclopropylamines from β-chloroimines and application towards the synthesis of 1-amino-2,2-dialkylcyclopropane-carboxylic acids

Base-induced 1,5-dehydrochlorination of β-chloroimines, having a relatively acidic hydrogen atom at carbon-1 of the N-substituent (e.g. benzyl, methoxycarbonylmethyl, α-methylbenzyl), afforded N-cyclopropylimines which were easily hydrolyzed into cyclopropylamines. This synthetic methodology was applied to the synthesis of the potentially plant growth regulating 1-amino-2,2-dialkylcyclopropanecarboxylic acids via oxidation with catalytic ruthenium(IV)oxide/sodium periodate of suitably N-protected 1-aryl-2,2-dialkylcyclopropylamines.

SYNTHESIS OF 2,2-DIMETHYL-1-AMINOCYCLOPROPANECARBOXYLIC ACID FROM β-CHLOROIMINES

2,2-Dimethyl-ACC, a potential plant growth regulator, was synthesized by cyclopropanation of β-chloroimines.