109296-40-4Relevant academic research and scientific papers
A New Method for the Preparation of 2,2-Dialkylcyclopropylamines
Sulmon, Paul,Kimpe, Norbert De,Schamp, Niceas
, p. 1677 - 1678 (1986)
2,2-Dialkylcyclopropylamines have been prepared by a new synthetic method involving base-induced cyclization of β-chloroimines and subsequent hydrolysis.
Synthesis of 2,2-dialkylcyclopropylamines from β-chloroimines and application towards the synthesis of 1-amino-2,2-dialkylcyclopropane-carboxylic acids
De Kimpe,Sulmon,Boeykens
, p. 3389 - 3406 (2007/10/07)
Base-induced 1,5-dehydrochlorination of β-chloroimines, having a relatively acidic hydrogen atom at carbon-1 of the N-substituent (e.g. benzyl, methoxycarbonylmethyl, α-methylbenzyl), afforded N-cyclopropylimines which were easily hydrolyzed into cyclopropylamines. This synthetic methodology was applied to the synthesis of the potentially plant growth regulating 1-amino-2,2-dialkylcyclopropanecarboxylic acids via oxidation with catalytic ruthenium(IV)oxide/sodium periodate of suitably N-protected 1-aryl-2,2-dialkylcyclopropylamines.
SYNTHESIS OF 2,2-DIMETHYL-1-AMINOCYCLOPROPANECARBOXYLIC ACID FROM β-CHLOROIMINES
Kimpe, Norbert De,Sulmon, Paul,Schamp, Niceas
, p. 5029 - 5032 (2007/10/02)
2,2-Dimethyl-ACC, a potential plant growth regulator, was synthesized by cyclopropanation of β-chloroimines.
