1092977-06-4

Upstream product

• 1092977-07-5 2-(3-butoxyphenyl)-N-tert-butoxycarbonylethylamine 
• 129150-68-1 N-(t-butoxycarbonyl)-2-(3-hydroxyphenyl)-ethylamine 
• 132513-29-2 tert-butyl {2-[3-(benzyloxy)phenyl]ethyl}carbamate 
• 29973-97-5 2-(3-benzyloxyphenyl)ethyl amine hydrochloride 
• 2039-67-0 2-(3-methoxyphenyl)-1-ethanamine 
• 30609-20-2 3-n-Butoxybenzaldehyde 
• 100-83-4 meta-hydroxybenzaldehyde 
• 1092977-61-1 2-[2-(3-butoxyphenyl)ethylamino]-N,N-dimethylacetamide 
• 1092977-08-6 2-(2-(3-butoxyphenyl)-N-tert-butoxycarbonylethylamino)-N,N-dimethylacetamide 

Relevant academic research and scientific papers

PROCESS FOR THE PRODUCTION OF SUBSTITUTED 2-[2-(PHENYL) ETHYLAMINO]ALKANEAMIDE DERIVATIVES

The present invention relates to a new process for the production of substituted 2-[2-(phenyl) ethylaminojalkaneamide derivatives of the following formula (I), in particular 2-[2-(3-butoxyphenyl)-ethylamino]-N,N-dimethylacetamide in high yields with very

PROCESS FOR THE PRODUCTION OF SUBSTITUTED 2-[2-(PHENYL) ETHYLAMINO]ALKANEAMIDE DERIVATIVES

The present invention refers to a process for preparing a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R is (C3-C10)alkyl, or ω-trifluoro(C3-C10)alkyl; R1 and R2 are, independently, hydrogen, hydroxy, (C1-C8) alkoxy, (C1-C8) alkylthio, halo, trifluoromethyl or 2,2,2-trifluoroethyl; or one of R1 and R2 is in ortho position to the R-O- group and, taken together with the same R-O-, represents a Formula (A) group where Ro is (C2-C9)alkyl; R3 and R4 are, independently, hydrogen, (C1-C4)alkyl; or R4 is hydrogen and R5 is a group selected from -CH2-OH, -CH2-O-(C1-C6)alkyl, -CH(CH3)-OH, -(CH2)2-S-CH3, benzyl and 4-hydroxybenzyl; or R4 and R5, taken together with the adjacent carbon atom, form a (C3-C6)cycloalkyl residue; R5 and R6 are independently hydrogen or (C1-C6)alkyl; or taken together with the adjacent nitrogen atom form a 5-6 membered monocyclic saturated heterocycle, optionally containing one additional heteroatom chosen among -O-, -S- and -NR7- where R7 is hydrogen or (C1-C6) alkyl; and wherein optionally one or more hydrogen atom in the groups R, R1, R2, R3, R4, R5 and R6, preferably in the R group, can be substituted by a deuterium atom.

SUBSTITUTED 2- [2- (PHENYL) ETHYLAMINO] ALKANEAMIDE DERIVATIVES AND THEIR USE AS SODIUM AND/OR CALCIUM CHANNEL MODULATORS

Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives of formula (I) wherein X, Y, Z, R, R1, R2, R3, R'3, R4, R5, R6, R7 have the meanings defined in the specifi