109355-93-3Relevant academic research and scientific papers
8H-Isoquinonaphthydrin-8-ones: synthesis of the Alangium alkaloids, alangimaridine and alangimarine
Brook, Jahangir Michael A.,MacLean, David B.,Holland, Herbert L.
, p. 2362 - 2368 (2007/10/02)
It is shown that 3,4-dihydroisoquinolines are activated toward nucleophilic attack by reaction with trimethylsilyl trifluoromethanesulfonate.The complex so formed reacts readily with the lithio derivative of 3-cyano-4-methyl-5-vinylpyridine, affording in
Activated Imines as Carbon Electrophiles: Applications in Alkaloid Synthesis
Jahangir,MacLean, David B.,Brook, Michael A.,Holland, Herbert L.
, p. 1608 - 1609 (2007/10/02)
3,4-Dihydroisoquinolines and 3,4-dihydro-β-carbolines react with trimethylsilyl trifluoromethanesulphonate to form complexes that react readily with the lithio derivatives of 3-cyano-4-methylpyridines; the method has been applied to the synthesis of the Alangium alkaloids, (+/-)-alangimaridine and alangimarine.
