109371-20-2

Basic information

• Product Name: 4-CHLORO-2,3,5-TRIMETHYLPYRIDINE-1-OXIDE
• Synonyms: 4-CHLORO-2,3,5-TRIMETHYLPYRIDINE-1-OXIDE;4-CHLORO-2,3,5-TRIMETHYLPYRIDINE-N-OXIDE;4-CHLORO-2,3,5-TRIMETHYLPYRIDINIUM-1-OLATE;2,3,5-TRIMETHYL 4-CHLORO PYRIDINE N-OXIDE;Pyridine,4-chloro-2,3,5-triMethyl-, 1-oxide;Pyridine,4-chloro-2,3,5-triMethyl-;4-chloro-2,3,5-trimethyl-1-oxidopyridin-1-ium
• CAS NO: 109371-20-2
• Molecular Formula: C₈H₁₀ClNO
• Molecular Weight: 171.62
• Mol File: 109371-20-2.mol
• Article Data: 9

Chemical Properties

• Melting Point: 148 °C
• Boiling Point: 347°C at 760 mmHg
• Flash Point: 163.7°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 0.000111mmHg at 25°C
• Refractive Index: 1.532
• PKA: 1.52±0.10(Predicted)
• CAS DataBase Reference: 4-CHLORO-2,3,5-TRIMETHYLPYRIDINE-1-OXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2,3,5-TRIMETHYLPYRIDINE-1-OXIDE(109371-20-2)
• EPA Substance Registry System: 4-CHLORO-2,3,5-TRIMETHYLPYRIDINE-1-OXIDE(109371-20-2)

Safety Data

• Hazardous Substances Data: 109371-20-2(Hazardous Substances Data)

Usage

General Description

4-CHLORO-2,3,5-TRIMETHYLPYRIDINE-1-OXIDE is a chemical compound with a molecular formula of C7H9NOCl. It is a pyridine derivative with a chloro substituent at the 4-position and three methyl groups at the 2, 3, and 5 positions. 4-CHLORO-2,3,5-TRIMETHYLPYRIDINE-1-OXIDE is commonly used in the pharmaceutical industry as a building block for the synthesis of various medications. It is also utilized as an intermediate in organic synthesis and chemical research. 4-CHLORO-2,3,5-TRIMETHYLPYRIDINE-1-OXIDE must be handled and stored carefully, as it is a potentially hazardous substance.

InChI:InChI=1/C8H10ClNO/c1-5-4-10(11)7(3)6(2)8(5)9/h4H,1-3H3

Upstream product

• 695-98-7 2,3,5-trimethyl-pyridine 
• 86604-79-7 2,3,5-trimethyl-4-nitropyridine N-oxide 
• 109371-18-8 4-chloro-2,3,5-trimethylpyridine 
• 109371-16-6 4-hydroxy-3,5,6-trimethyl-2(1H)-pyridone 
• 109371-17-7 2,4-dichloro-3,5,6-trimethylpyridine 

Downstream Products

• 86604-80-0 4-methoxy-2,3,5-trimethylpyridine 1-oxide 
• 96300-88-8 2-Hydroxymethyl-4-methoxy-3,5-dimethylpyridine hydrochloride 
• 91219-90-8 (4-methoxy-3,5-dimethyl-pyridin-2-yl)methyl acetate 
• 86604-75-3 2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride 
• 913696-26-1 4-((2,2-dimethyl-1,3-dioxan-5-yl)methoxy)-2,3,5-trimethylpyridine1-oxide 
• 109371-18-8 4-chloro-2,3,5-trimethylpyridine 
• 113618-20-5 4-(2,3,5-Trimethyl-pyridin-4-yl)-morpholine 
• 142885-96-9 2-chloromethyl-4-chloro-3,5-dimethylpyridine 

Relevant articles and documents

BENZIMIDAZOLE COMPOUND HAVING GASTRIC ACID SECRETION INHIBITORY ACTIVITY

The present invention provides a compound that has superior gastric acid secretion inhibitory action, ample long-lasting gastric acid secretion inhibitory action, and is able to maintain intragastric pH at a high level for an extended period of time, making it useful as a therapeutic or prophylactic agent for diseases or symptoms caused by gastric acid, as well as an active form of this compound (form to which the compound is converted in the body following administration thereof) in the form of a compound represented by general formula (1 a) (wherein R2 represents a group represented by formula (I) or the like, and R1, R3, W1 and X- are as defined in the description).

PROCESS FOR THE PRODUCTION OF 2- [ [4- T (2, 2-DIMETHYL-1, 3-DIOXAN-5-YL) METHOXY] PYRIDIN-2-YL] METHYLTHIO] -1H-BENZIMIDAZOLE

It is an object of the present invention to provide a process for the production on an industrial scale of a compound (1) or a salt thereof. There is provided a process for the production of compound (1) represented by the formula or a salt thereof: (wherein R1 and R3 independently represents a hydrogen atom or a methyl group), the process comprising the steps of: (a) reacting together a compound (3T) represented by the formula: (wherein X1 represents a leaving group, and R1 and R3 are defined as above) and (2,2-dimethyl-1,3-dioxan-5-yl)methanol represented by the formula or a salt thereof: so as to produce a compound (2T) represented by the formula (wherein R1 and R3 are defined as above); and (b) reacting the compound represented by above formula (2T) with an oxidizing agent.

Benzimidazole compound

An object of the present invention is to provide a novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases, having an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.