86604-80-0Relevant articles and documents
Synthesis method of 4-methoxy-2, 3, 5-trimethyl-pyridine nitrogen oxide
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Paragraph 0017-0018, (2021/04/14)
The invention discloses a synthesis method of 4-methoxy-2, 3, 5-trimethyl-pyridine nitrogen oxide, which comprises the following steps: S1, carrying out bromination reaction and methoxy substitution on 2, 3, 5-trimethylpyridine-N-oxide to obtain 4-bromine-2, 3, 5-trimethyl-pyridine nitrogen oxide; and S2, carrying out a sodium methoxide substitution reaction on the 4-bromo-2, 3, 5-trimethyl-pyridine nitrogen oxide to generate an important intermediate 4-methoxy-2, 3, 5-trimethyl-pyridine nitrogen oxide of omeprazole. According to the method, bromate and bromide which are mild bromination reaction conditions are adopted in the process route, then the bromate intermediate is used for carrying out methoxy substitution reaction, and the whole process is simple in design, mild in reaction condition and easy and convenient to operate.
Diversified synthesis of novel quinoline and dibenzo thiazepine derivatives using known active intermediates
Sharada,Satyanarayana Reddy,Sammaiah,Sumalatha
, p. 7959 - 7966 (2013/09/23)
The novel drug development to control resisting infections in conventional drug therapy is a need of today. Few antiulcer relative derivatives developed by approaching convergent synthesis. The derivatives synthesized successfully are dibenzo thiazepine-pyridine (SLN11-SLN15) and benzimidazole-hydroquinoline based derivatives (SLN16-SLN20). It involved the coupling through microwave, sonication and conventional techniques at final step. The efficient technology identified as sonication technique basically time and yield. The reported compounds were structural characterized by elemental analysis and spectral studies such as 1H, 13C NMR and MS.
1,3,4-oxadiazoles
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, (2008/06/13)
1,3,4-oxadiazole compounds are disclosed. The subject compounds suppress immune function and have hepatoprotection activity.
