1093757-06-2Relevant academic research and scientific papers
Effect of indole-3-acetic acid analogs on the differentiation of HL-60 cells
Lien, Jin-Cherng,Jiang, Yu-Dong,Chen, Chun-Jen,Kuo, Sheng-Chu,Huang, Li-Jiau
, p. 1160 - 1165 (2008)
In continuing search for novel cell differentiation agents, a series of derivatives of indole-3-acetic acid and indole-3-carboxylic acid were prepared and tested against HL-60 cells for their differentiation and antiproliferation activities. Among them, N-ethyl-1-benzylindole-3-carboxamide (14) was the most potent, whereas N-methyl 1-benzylindole-3-acetamide (5) and N-methyl 1-benzylindole-3-carboxamide (13) synergistically potentiated with all-trans-retinoic acid to induce cell differentiation as well as antiproliferation. Our results indicate that these compounds are effective cell differentiation and antiproliferation agents in combination with retinoic acid.
